Use of oral misoprostol in the prevention of postpartum haemorrhage
Article first published online: 19 AUG 2005
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 104, Issue 3, pages 336–339, March 1997
How to Cite
El-Refaey, H., O'Brien, P., Morafa, W., Walder, J. and Rodeck, C. (1997), Use of oral misoprostol in the prevention of postpartum haemorrhage. BJOG: An International Journal of Obstetrics & Gynaecology, 104: 336–339. doi: 10.1111/j.1471-0528.1997.tb11464.x
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 25 April 1996 Accepted 27 November 1996
Objective To investigate the use of the oral prostaglandin E1 analogue, misoprostol in the prevention of postpartum haemorrhage.
Design A prospective observational study.
Setting A university teaching hospital.
Participants Two hundred and thirty-seven consecutive women undergoing vaginal delivery.
Methods All the women were given 600 μg oral misoprostol just after delivery.
Main outcome measures Rates of postpartum haemorrhage; need for therapeutic oxytocic drugs; retained placenta and length of the third stage of labour.
Results Postpartum haemorrhage occurred in 6% of the women; the need for therapeutic oxytocics in 5%, retained placenta in 2% and the median length of the third stage was 5 min. Vomiting and diarrhoea in the first hour after delivery occurred in 8% and 3% respectively and shivering in 60%.
Conclusions Misoprostol may be effective in the prevention of postpartum haemorrhage, and has few side effects. A double blind randomised trial is required.