Randomised placebo controlled trial of mefenamic acid for premedication at outpatient hysteroscopy: a pilot study

Authors

  • Fritz Nagele,

    Visiting Research Fellow
    1. Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, The Royal Free Hospital, London
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  • Gillian Lockwoodb,

    Clinical Research Fellow
    1. Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford
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  • Adam L. Magos

    Consultant (Obstetrics and Gynaecology) , Corresponding author
    1. Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, The Royal Free Hospital, London
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Correspondence: Mr A. L. Magos, Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, The Royal Free Hospital, Pond Street, Hampstead, London NWS 2QG, UK.

Abstract

An increasing number of diagnostic hysteroscopies are being performed in an outpatient setting. Most women tolerate the examination well, but die single commonest reason for failure is pain. We assessed the efficacy of a nonsteroidal, anti-inflammatory analgesic as premedication before hysteroscopy in a double-blind, placebo controlled trial. Our results showed that 500 mg mefenamic acid given one hour before hysteroscopy had no significant benefit in the discomfort experienced during the procedure but did signficantly reduce pain after hysteroscopy. A larger dose or a longer interval between premedication and hysteroscopy may possibly be associated with greater benefits.

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