Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence
Article first published online: 19 AUG 2005
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 104, Issue 9, pages 994–998, September 1997
How to Cite
Keane, D. P., Sims, T. J., Abrams, P. and Bailey, A. J. (1997), Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence. BJOG: An International Journal of Obstetrics & Gynaecology, 104: 994–998. doi: 10.1111/j.1471-0528.1997.tb12055.x
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 13 February 1997 Accepted 11 June 1997
Objective To determine if differences exist in the collagen status of premenopausal nulliparous women with genuine stress incontinence compared with continent controls.
Design Thirty-six premenopausal nulliparous women with urodynamically-proven genuine stress incontinence were compared with 25 controls. All the women studied had a periurethral vaginal biopsy taken of approximately 30–50 mg in wet weight. This biopsy was then analysed to determine the collagen content, the type I:III collagen ratio and the collagen cross-link content.
Setting A tertiary referral urodynamic unit.
Results The nulliparous women with genuine stress incontinence had significantly less collagen in their tissues (P < 0.0001) compared with the continent controls. In addition, there was a decreased ratio of type I to type III collagen (P= 0.0008), and the cross-link content was also significantly reduced in the women with genuine stress incontinence (P < 0.0001).
Conclusion Genuine stress incontinence is present in a significant number of women before childbirth. The aetiology of their incontinence appears to be due to a defect in their connective tissue, with both a quantitative and qualitative reduction in their collagen.