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Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer

  1. Thomas Ind Specialist Registrar 1,*,
  2. Ray Iles Lecturer 2,
  3. John Shepherd Consultant 2,
  4. Tim Chard Professor 2

Article first published online: 19 AUG 2005

DOI: 10.1111/j.1471-0528.1997.tb12061.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 104, Issue 9, pages 1024–1029, September 1997

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How to Cite

Ind, T., Iles, R., Shepherd, J. and Chard, T. (1997), Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer. BJOG: An International Journal of Obstetrics & Gynaecology, 104: 1024–1029. doi: 10.1111/j.1471-0528.1997.tb12061.x

Author Information

  1. 1

    Department of Obstetrics and Gynaecology, Hillingdon Hospital, Uxbridge

  2. 2

    Department of Obstetrics and Gynaecology, St Bartholomew's and The Royal London Hospital School of Medicine and Dentistry, London

*Correspondence: Mr T. Ind, Department of Obstetrics and Gynaecology, Watford Hospital, Vicarage Road, Watford WD1 8HB, UK.

Publication History

  1. Issue published online: 19 AUG 2005
  2. Article first published online: 19 AUG 2005
  3. Received 3 December 1996 Accepted 14 April 1997

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Objective To investigate the prognostic significance of elevated levels of cancer antigen 125 (CA125), placental alkaline phosphatase (PLAP), free β human chorionic gonadotrophin (hCG) and cancer-associated serum antigen (CASA) in women with primary epithelial ovarian carcinoma.

Design A two year follow up study of survival.

Setting A tertiary care gynaecological oncology unit.

Participants One hundred and eleven women with histologically confirmed epithelial ovarian cancer.

Main outcome measures Survival over a two year period.

Results Stage corrected log-rank χ2 tests demonstrated a significant effect on survival for all four tumour markers (CA125 P= 0.0142; PLAP P < 0.0001; CASA P= 0.0098; hCG P= 0.0002). This was confirmed when each variable was fitted together with disease stage in Cox proportional hazard models. When fitted as multiple variables in a Cox proportional hazard model, the addition of free β- hCG and CASA to disease stage, PLAP concentrations and CA125 levels did not demonstrate further prognostic value.

Conclusions Levels of all four markers correlate with survival in patients with epithelial ovarian cancer. The combination of PLAP and CA125 concentrations together with disease stage may be used to predict survival but the addition of hCG and CASA levels do not give additional prognostic information.

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