Antibodies against copper-oxidised and malondialdehyde-modified low density lipoproteins in pre-eclamptic pregnancies

Authors

  • Jukka Uotila,

    Consultant (Obstetrics and Gynaecology) , Corresponding author
    1. Departments of Obstetrics and Gynaecology, Tampere University Hospital
    Search for more papers by this author
  • Tiina Solakivi,

    Research Scientist (Clinical Chemistry)
    1. Departments of Clinical Chemistry and Research Laboratory for Atherosclerosis, Tampere University Hospital
    Search for more papers by this author
  • Olli Jaakkola,

    Senior Lecturer (Medical Biochemistry)
    1. Department of Medical Biochemistry, Medical School, University of Tampere, Finland
    Search for more papers by this author
  • Risto Tuimala,

    Senior Lecturer (Obstetrics and Gynaecology)
    1. Departments of Obstetrics and Gynaecology, Tampere University Hospital
    Search for more papers by this author
  • Terho Lehtimaki

    Senior Lecturer (Clinical Chemistry)
    1. Departments of Clinical Chemistry and Research Laboratory for Atherosclerosis, Tampere University Hospital
    2. Department of Medical Biochemistry, Medical School, University of Tampere, Finland
    Search for more papers by this author

Correspondence: Dr J. Uotila, Department of Obstetrics and Gynaecology, Tampere University Hospital, 33,520 Tampere, Finland.

Abstract

Objective To measure auto-antibodies against oxidatively modified low density lipoprotein (LDL) in pre-eclamptic pregnancies using two different techniques.

Design Clinical study comparing pre-eclamptic and normal pregnancies.

Setting Tampere University Hospital, Finland.

Population Twenty-one primigravidae with pre-eclampsia and 13 healthy, normotensive primigravidae as controls.

Methods The serum titers of antibodies against both malondialdehyde-modified and copper-oxidised LDL (MDA-LDL and copper-ox LDL) were analysed and related to parameters reflecting the severity of pre-eclampsia.

Results There was a positive correlation (r= 0.58) between antibodies against MDA-LDL and copper-ox LDL in women with pre-eclampsia but not in healthy pregnant controls. The antibody levels against copper-ox LDL, but not against MDA-LDL, were higher in women with pre-eclampsia than in women with a normal pregnancy (P < 0.01). While the antibody titers against copper-ox LDL did not correlate with any parameter reflecting the severity of pre-eclampsia, those against MDA-LDL showed a positive correlation with the level of diastolic blood pressure (r= 0.54) and a negative correlation with platelet count (r= 461) in women with pre-eclampsia.

Conclusions There are increased titers of serum autoantibodies against copper-oxidised LDL in pre-eclampsia, which may reflect enhanced lipid peroxidation involving circulating lipoproteins.

Ancillary