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Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole
Article first published online: 19 AUG 2005
DOI: 10.1111/j.1471-0528.1998.tb10233.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 105, Issue 8, pages 877–881, August 1998
Additional Information
How to Cite
Källén, B. (1998), Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole. BJOG: An International Journal of Obstetrics & Gynaecology, 105: 877–881. doi: 10.1111/j.1471-0528.1998.tb10233.x
Publication History
- Issue published online: 19 AUG 2005
- Article first published online: 19 AUG 2005
- Received 5 February 1998 Returned for revision 8 May 1998 Accepted 29 May 1998
- Abstract
- Article
- References
- Cited By
Objective To study delivery outcome after maternal use of acid-suppressing drugs during early pregnancy.
Design Cohort study of women identified by interview in early pregnancy.
Population Sweden women giving birth from 1995 to early 1997.
Methods Comparison of infants exposed to acid-suppressing drugs with all births in 1995–1996.
Main outcome measures Presence of congenital malformations.
Results Proton pump blockers were used by 275 women, H2 receptor antagonists by 255 women, and both categories of drugs by 20 women. No effect of the use of omeprazole or H2-receptor antagonists on the rate of congenital malformations could be demonstrated.
Conclusions Though a teratogenic effect of these drugs cannot be completely ruled out, the individual risk after exposures during the first trimester seems to be negligible.