Site of origin of epithelial ovarian cancer: the endometriosis connection

Authors

  • Paolo Vercellini,

    Assistant Professor (Obstetrics and Gynaecology), Corresponding author
    1. Department of Obstetrics and Gynaecology ‘Luigi Mangiagalli’, University of Milan
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  • Giovanna Scarfone,

    Research Fellow (Gynaecological Oncology)
    1. Division of Gynaecologic Oncology, National Institute for Cancer Treatment, Milan, Italy
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  • Giorgio Bolis,

    Associate Professor (Gynaecological Oncology)
    1. Division of Gynaecologic Oncology, National Institute for Cancer Treatment, Milan, Italy
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  • Giovanna Stellato,

    Research Fellow (Obstetrics and Gynaecology)
    1. Department of Obstetrics and Gynaecology ‘Luigi Mangiagalli’, University of Milan
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  • Silvestro Carinelli,

    Chief of Division (Pathology)
    1. Department of Obstetrics and Gynaecology ‘Luigi Mangiagalli’, University of Milan
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  • Pier Giorgio Crosignani

    Professor (Obstetrics and Gynaecology)
    1. Department of Obstetrics and Gynaecology ‘Luigi Mangiagalli’, University of Milan
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Correspondence: Dr P. Vercellini, Clinica Ostetrica e Ginecologica ‘Luigi Mangiagalli’, Via Commenda 12, 20122 Milano, Italy.

Abstract

To investigate the left- and right-sided distribution of ovarian malignant surface epithelial tumours, data were collected on 209 women undergoing first-line surgery for Stage I and II disease. Considering the unilateral cancers, the observed proportion of left-sided lesions was 35/54 (65%) in the endometrioid, 20/45 (44%) in the serous, 19/35 (54%) in the clear cell, 13/29 (45%) in the mucinous, 2/8 (25%) in the mixed, and 2/5 (40%) in the undifferentiated histological type group. The proportion of left-sided unilateral endometrioid cancers was significantly different from the expected 50% (χ21, 4.74, P= 0.03) and very similar to that previously observed for benign endometriotic cysts, constituting further evidence in favour of a possible development of endometrioid cancers from the latter lesions.

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