The p53 codon 72 polymorphism in black South African women and the risk of cervical cancer

Authors

  • Rosemary Pegoraro,

    Senior Research Fellow, Corresponding author
    1. Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa
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  • Jack Moodley,

    Professor
    1. Department of Obstetrics and Gynaecology and MRC/UN Pregnancy Hypertension Research Unit, University of Natal Medical School, Durban, South Africa
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  • Shunbagavelli Naiker,

    Registrar
    1. Department of Obstetrics and Gynaecology and MRC/UN Pregnancy Hypertension Research Unit, University of Natal Medical School, Durban, South Africa
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  • Pamela Lanning,

    Medical Technologist
    1. Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa
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  • Lee Rom

    Medical Technologist
    1. Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa
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Correspondence: Dr R. J. Pegoraro, Department of Chemical Pathology, University of Natal Medical School, Private Bag 7, Congella 4013, South Africa.

Abstract

The p53 codon 72 genotype was examined in blood samples taken from 121 Zulu-speaking black South African women with histologically proven squamous carcinoma of the cervix. Freshly biopsied tumour tissue was also available for human papillomavirus subtyping from 100 of these women. A control group consisted of 251 healthy race-matched women attending a contraceptive service facility. The results show that there were no statistically significant differences in the frequency of the homozygous arginine genotype between patients with cancer of cervix, irrespective of human papillomavirus status, and healthy controls. This finding suggests that the arginine allele does not predispose towards viral tumour genesis in this population, and supports the findings of research done in other ethnic groups.

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