Polymorphisms in various coagulation genes in black South African women with placental abruption

Authors

  • B. Hira,

    1. MRC/UN Pregnancy Hypertension Research Unit and Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
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  • R.J. Pegoraro,

    1. Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
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  • L. Rom,

    1. Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
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  • T. Govender,

    1. Department of Chemical Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
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  • J. Moodley

    Corresponding author
    1. MRC/UN Pregnancy Hypertension Research Unit and Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
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*Professor J. Moodley, Department of Obstetrics and Gynaecology, Nelson R. Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013, South Africa.

Abstract

This pilot study examined Factor V Leiden (R506Q), prothrombin (20210G → A), thrombomodulin (A455V) and MTHFR (677C →T) in 100 Zulu-speaking black South African women with placental abruption and 217 controls. The Factor V Leiden and prothrombin variant gene alleles were not detected in either patient or control groups. The thrombomodulin polymorphic variant was not seen in the patient group but three heterozygotes (1%) were found in the controls. No homozygotes for the MTHFR T677 variant were detected in the patients but two (1%) were noted in the controls; the normal and heterozygote genotype and allele frequencies for this polymorphism were similar in the two groups.

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