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Isolated oligohydramnios is not associated with adverse perinatal outcomes

  1. Jun Zhang1,*,
  2. James Troendle1,
  3. Susan Meikle2,
  4. Mark A. Klebanoff1,
  5. William F. Rayburn3

Article first published online: 11 FEB 2004

DOI: 10.1111/j.1471-0528.2004.00060.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 111, Issue 3, pages 220–225, March 2004

Additional Information

How to Cite

Zhang, J., Troendle, J., Meikle, S., Klebanoff, M. A. and Rayburn, W. F. (2004), Isolated oligohydramnios is not associated with adverse perinatal outcomes. BJOG: An International Journal of Obstetrics & Gynaecology, 111: 220–225. doi: 10.1111/j.1471-0528.2004.00060.x

Author Information

  1. 1

    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA

  2. 2

    Center for Research on Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA

  3. 3

    Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

* *Dr J. Zhang, Epidemiology Branch, National Institute of Child Health and Human Development, NIH Building 6100, Room 7B03, Bethesda, Maryland 20892, USA.

Publication History

  1. Issue published online: 11 FEB 2004
  2. Article first published online: 11 FEB 2004

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Objective  To examine fetal growth and perinatal outcomes in pregnancies with isolated oligohydramnios.

Design  A cohort study.

Setting  Multiple clinics and hospitals.

Population  Low risk pregnant women.

Methods  We used data from the multicentre clinical trial of Routine Antenatal Diagnostic Imaging with UltraSound (RADIUS), in which 15,151 low risk pregnant women were randomly assigned to the ultrasound screening group or the control group. Women in the screening group underwent sonographic exams at 15–22 and 31–35 weeks of gestation. Both groups could have clinically indicated sonographic exams at any time.

Main outcome measures  We used changes of fetal weight z-score to assess whether fetal growth was compromised from the diagnosis of oligohydramnios until delivery, using a repeated-measures regression. We used a combined perinatal index as an indicator of adverse perinatal outcome, which consisted of severe perinatal morbidity and mortality.

Results  Oligohydramnios (amniotic fluid index ≤5 cm) was diagnosed in 1.5% (113/7617) of women with ultrasound screening compared with 0.8% (57/7534) among the controls. Approximately half of the oligohydramnios cases in the screening group were isolated with no clearly associated factors (e.g. premature rupture of the fetal membranes, congenital anomalies, diabetes, hypertension, postdate and intrauterine growth restriction). Fetal weight centiles in isolated oligohydramnios cases did not change significantly from diagnosis until delivery. Pregnancies with isolated oligohydramnios had perinatal outcomes similar to pregnancies with a normal amniotic fluid index.

Conclusion  Isolated oligohydramnios is not associated with impaired fetal growth or an increased risk of adverse perinatal outcomes.

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