T594M mutation of the epithelial sodium channel β-subunit gene in pre-eclampsia and eclampsia in Black South African women

Authors

  • R.J. Pegoraro,

    1. Department of Chemical Pathology, Nelson R. Mandela School of Medicine, University of Natal, Congella, Durban, South Africa
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  • C.B. Roberts,

    1. Department of Obstetrics and Gynaecology, MRC/UN Pregnancy Hypertension Research Unit, Nelson R. Mandela School of Medicine, University of Natal, Congella, Durban, South Africa
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  • L. Rom,

    1. Department of Chemical Pathology, Nelson R. Mandela School of Medicine, University of Natal, Congella, Durban, South Africa
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  • J. Moodley

    1. Department of Obstetrics and Gynaecology, MRC/UN Pregnancy Hypertension Research Unit, Nelson R. Mandela School of Medicine, University of Natal, Congella, Durban, South Africa
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Dr R. J. Pegoraro, Department of Chemical Pathology, Nelson R. Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013 South Africa.

Abstract

The possible role of the β-subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre-eclampsia (n= 204), early onset pre-eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 women from the same ethnic group who had full-term normotensive pregnancies, for the presence of the T594M polymorphism. The variant allele was detected in 1.7% to 3.8% of the various patient groups and in 3.6% of the control group reflecting no significant difference. These results suggest that the T594M polymorphism in the sodium channel β-subunit is not associated with the pathogenesis of pre-eclampsia or gestational hypertension.

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