Misoprostol for second trimester pregnancy termination in women with prior caesarean section
Article first published online: 13 SEP 2004
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 112, Issue 1, pages 97–99, January 2005
How to Cite
Daskalakis, G. J., Mesogitis, S. A., Papantoniou, N. E., Moulopoulos, G. G., Papapanagiotou, A. A. and Antsaklis, A. J. (2005), Misoprostol for second trimester pregnancy termination in women with prior caesarean section. BJOG: An International Journal of Obstetrics & Gynaecology, 112: 97–99. doi: 10.1111/j.1471-0528.2004.00285.x
- Issue published online: 13 SEP 2004
- Article first published online: 13 SEP 2004
Objective To examine whether a previous caesarean section increases the risk for complications in women undergoing a mid-trimester pregnancy termination by labour induction.
Design Retrospective analysis of case records between 1997 and 2002.
Setting Fetal Medicine Unit of a large teaching hospital.
Population One hundred and eight women with a previous caesarean section (study group) and 216 women without such a history (controls), who underwent a second trimester termination of pregnancy.
Methods All the terminations were performed between 17 and 24 weeks of gestation by using 400 μg of oral administration of misoprostol in combination with 400 μg of intravaginal misoprostol. The same dose of intravaginal misoprostol was repeated every 6 hours for a maximum of five doses.
Main outcome measures Severe haemorrhage requiring blood transfusion, post-abortal infection, retained placenta and uterine rupture.
Result Complications occurred in 16 out of 108 women of the study group (15%) and in 26 out of 216 of the controls (12%), with only one ruptured uterus in the control group.
Conclusion We found no evidence that a previous caesarean delivery affects the incidence of complications when women with such a history undergo a mid-trimester pregnancy termination with misoprostol.