The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders
Article first published online: 22 NOV 2004
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 111, Issue 12, pages 1425–1428, December 2004
How to Cite
Kingman, C.E.C., Kadir, R.A., Lee, C.A. and Economides, D.L. (2004), The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders. BJOG: An International Journal of Obstetrics & Gynaecology, 111: 1425–1428. doi: 10.1111/j.1471-0528.2004.00305.x
- Issue published online: 22 NOV 2004
- Article first published online: 22 NOV 2004
Background The levonorgestrel-releasing intrauterine system (LNG-IUS) is used commonly by gynaecologists as a contraceptive and to treat menorrhagia. However, its efficacy has not been examined in women with inherited bleeding disorders.
Design A prospective pilot study.
Setting A teaching hospital in north London with a designated haemophilia centre.
Population Female patients with a known inherited bleeding disorder.
Methods Sixteen women with subjective and objective menorrhagia caused by inherited bleeding disorders (13 von Willebrand's Disease, two factor XI deficiency and one Hermansky–Pudlak syndrome), who had previously undergone unsuccessful medical treatment were followed up for nine months after LNG-IUS insertion. Bleeding was measured by pictorial chart and haemoglobin concentration.
Main outcome measure
Results All women reported that their periods were improved, pictorial chart scores were lower and 56% became amenorrhoeic. None reported side effects.
Conclusion The LNG-IUS is well tolerated and effective and improves quality of life.