General gynaecology: Intrauterine lignocaine as an anaesthetic during endometrial sampling: a randomised double-blind controlled trial


Dr SK Hui, Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Hong Kong, China.


Objective  To evaluate the effectiveness of intrauterine lignocaine as an anaesthetic during endometrial sampling.

Design  Prospective, randomised, double-blind, placebo-controlled trial.

Setting  Outpatient gynaecological minor operation unit in a public hospital.

Population  Two hundred premenopausal women scheduled for endometrial sampling because of abnormal uterine bleeding.

Methods  Transcervical intrauterine instillation of 5 mL of 2% lignocaine or 5 mL of normal saline before performing endometrial sampling with vacuum aspirator.

Main outcome measures  Evaluation of pain associated with the procedure using a visual analogue scale.

Results  The use of intrauterine lignocaine reduced pain during suction curettage in endometrial sampling.

Conclusions  Transcervical instillation of lignocaine reduced pain during endometrial sampling.