Heterogeneity in the origin of recurrent complete hydatidiform moles: not all women with multiple molar pregnancies have biparental moles

Authors

  • JJ Van Der Smagt,

    Corresponding author
    1. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
      JJ van der Smagt, Department of Medical Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands. Email j.j.vandersmagt@umcutrecht.nl
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  • E Scheenjes,

    1. Department of Obstetrics and Gynaecology, Ziekenhuis Gelderse Vallei, Ede, The Netherlands
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  • JAM Kremer,

    1. Department of Obstetrics and Gynaecology, University Medical Center St Radboud, Nijmegen, The Netherlands
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  • FAM Hennekam,

    1. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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  • RA Fisher

    1. Trophoblastic Screening and Treatment Centre, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK
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JJ van der Smagt, Department of Medical Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands. Email j.j.vandersmagt@umcutrecht.nl

Abstract

Hydatidiform moles of two women, each with three molar pregnancies, were examined in order to study their origin. Multiple recurrences have previously been associated with women who have biparental complete hydatidiform moles (CHM). However, all the moles examined in this study were androgenetic CHM (AnCHM), indicating that recurrent (>2) moles, particularly in the absence of a positive family history, may be androgenetic rather than biparental. These data suggest that some women have a specific liability for having AnCHM. Making the distinction between a biparental or an androgenetic origin of recurrent moles is of relevance for counselling and when considering therapeutic options. Therefore, we propose that all recurrent moles should be investigated using molecular techniques.

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