A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of pain following laparoscopy and dye

Authors

  • S Sripada,

    Corresponding author
    1. a Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UKb Department of Obstetrics and Gynaecology, Northtees and Hartlepool NHS Trust, Hartlepool, UKc Department of Obstetrics and Gynaecology and d Department of Anaesthesia, NHS Grampian, Foresterhill, Aberdeen, UKe Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Aberdeen, UK
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  • a S Roy,

    1. a Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UKb Department of Obstetrics and Gynaecology, Northtees and Hartlepool NHS Trust, Hartlepool, UKc Department of Obstetrics and Gynaecology and d Department of Anaesthesia, NHS Grampian, Foresterhill, Aberdeen, UKe Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Aberdeen, UK
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  • b M Mathur,

    1. a Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UKb Department of Obstetrics and Gynaecology, Northtees and Hartlepool NHS Trust, Hartlepool, UKc Department of Obstetrics and Gynaecology and d Department of Anaesthesia, NHS Grampian, Foresterhill, Aberdeen, UKe Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Aberdeen, UK
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  • c M Hamilton,

    1. a Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UKb Department of Obstetrics and Gynaecology, Northtees and Hartlepool NHS Trust, Hartlepool, UKc Department of Obstetrics and Gynaecology and d Department of Anaesthesia, NHS Grampian, Foresterhill, Aberdeen, UKe Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Aberdeen, UK
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  • c K Cranfield,

    1. a Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UKb Department of Obstetrics and Gynaecology, Northtees and Hartlepool NHS Trust, Hartlepool, UKc Department of Obstetrics and Gynaecology and d Department of Anaesthesia, NHS Grampian, Foresterhill, Aberdeen, UKe Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Aberdeen, UK
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  • and d S Bhattacharya e

    1. a Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, UKb Department of Obstetrics and Gynaecology, Northtees and Hartlepool NHS Trust, Hartlepool, UKc Department of Obstetrics and Gynaecology and d Department of Anaesthesia, NHS Grampian, Foresterhill, Aberdeen, UKe Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, Aberdeen, UK
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Dr S Sripada, Assisted Reproduction Unit, Aberdeen Maternity Hospital, Foresterhill, Aberdeen AB25 2ZD, UK. Email ogy302@abdn.ac.uk

Abstract

The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. Women received either 15 ml of 0.9% saline (n= 42) or 15 ml of 0.5% bupivacaine (n= 43), which was instilled intraperitoneally. Pain and nausea scores were recorded on a visual analogue scale (VAS). Pain perception was no different in the bupivacaine group compared with the control group with median values of VAS at 2 hours (18, 19; P= 0.8), 6 hours (21, 22; P= 0.5), 12 hours (19, 25; P= 0.8), 24 hours (27, 27; P= 0.9) and 48 hours (21, 13; P= 0.26). Women in the bupivacaine group were less nauseated than controls in the immediate postoperative period (with median VAS scores of 0, 8; P value = 0.03 at 2 hours and 0, 7; P= 0.01 at 6 hours).

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