Topical tacrolimus in the management of lichen sclerosus
Article first published online: 22 JUN 2006
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 113, Issue 7, pages 832–834, July 2006
How to Cite
Luesley, D. and Downey, G. (2006), Topical tacrolimus in the management of lichen sclerosus. BJOG: An International Journal of Obstetrics & Gynaecology, 113: 832–834. doi: 10.1111/j.1471-0528.2006.00977.x
- Issue published online: 22 JUN 2006
- Article first published online: 22 JUN 2006
- Accepted 19 April 2006.
- Benign vulval disease;
- lichen sclerosus;
The effective management of vulval lichen sclerosus (LS) currently depends upon the use of topical steroids and emollients. There are concerns with regard to the long-term toxicity of potent steroids and therefore is a need to consider effective alternatives. Immunomodulatory macrolactams offer an alternative to steroids in the management of some other inflammatory skin disorders and it would seem reasonable therefore to assess their activity in LS. This pilot study of 16 histologically confirmed cases of LS suggests that macrolactams have a positive pharmacological effect.