Compliance with routine antenatal rhesus D prophylaxis and the impact on sensitisations: observations over 14 years
Article first published online: 22 JUN 2006
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 113, Issue 7, pages 839–843, July 2006
How to Cite
MacKenzie, I., Findlay, J., Thompson, K. and Roseman, F. (2006), Compliance with routine antenatal rhesus D prophylaxis and the impact on sensitisations: observations over 14 years. BJOG: An International Journal of Obstetrics & Gynaecology, 113: 839–843. doi: 10.1111/j.1471-0528.2006.00988.x
- Issue published online: 22 JUN 2006
- Article first published online: 22 JUN 2006
- Accepted 25 April 2006.
- Antenatal prophylaxis;
- sensitisation rates
Documented routine antenatal anti-D prophylaxis was given to 90% and 81–87% of eligible women at 28 and 34 weeks of gestation, respectively, during the early 1990s and early 2000s. With increasing experience and education, a significant improvement in the timing of the first (OR 0.26, 95% CI 0.16–0.41: P < 0.0001) and second injections (OR 0.40, 95% CI 0.26–0.61: P < 0.0001) occurred during the latter period. Despite these improvements, there was no reduction in the sensitisation rate at 0.4%. However, this low rate occurred despite significant proportions of women delivering more than 42 days after the second injection. Fifteen of the 16 sensitised women had received routine antenatal prophylaxis.