The influence of body weight on response to ovulation induction with gonadotrophins in 335 women with World Health Organization group II anovulatory infertility
Article first published online: 10 AUG 2006
BJOG: An International Journal of Obstetrics & Gynaecology
Special Issue: Obesity
Volume 113, Issue 10, pages 1195–1202, October 2006
How to Cite
Balen, A., Platteau, P., Andersen, A., Devroey, P., Sørensen, P., Helmgaard, L. and Arce, J.-C. (2006), The influence of body weight on response to ovulation induction with gonadotrophins in 335 women with World Health Organization group II anovulatory infertility. BJOG: An International Journal of Obstetrics & Gynaecology, 113: 1195–1202. doi: 10.1111/j.1471-0528.2006.01034.x
- Issue published online: 10 AUG 2006
- Article first published online: 10 AUG 2006
- Accepted 15 June 2006. Published OnlineEarly 14 August 2006.
- body weight;
- ovulation induction;
- polycystic ovary syndrome
Objective To assess the influence of body weight on the outcome of ovulation induction in women with World Health Organization (WHO) group II anovulatory infertility.
Design The combined results of two studies in which either a highly purified urinary follicle-stimulating hormone or highly purified urinary menotrophin were compared with recombinant follicle-stimulating hormone.
Setting Thirty-six fertility clinics.
Population A total of 335 women with WHO group II anovulatory infertility failing to ovulate or conceive on clomifene citrate.
Methods Ovarian stimulation using a low-dose step-up protocol.
Main outcome measures The effects of body weight on ovarian response, ovulation rate and pregnancy rate after one treatment cycle.
Results With increasing body mass index (BMI), a higher threshold dose of gonadotrophins was required and there were more days of stimulation; yet, despite a greater concentration of antral follicles, there were fewer intermediate and large follicles. There was no difference in the rates of ovulation and clinical pregnancy in relation to body weight.
Conclusions Body weight affects gonadotrophin requirements but not overall outcome of ovulation induction in women with anovulatory polycystic ovary syndrome and a BMI of less than 35 kg/m2.