1471-0528/asset/BJO_left.gif?v=1&s=0fb87361cdb6be25fdf05019eed6d47f5143f610)
1471-0528/asset/olbannerright.gif?v=1&s=3892ef16ff18d6834c302faf85268a49f5fc588f)
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review
Article first published online: 12 JUN 2007
DOI: 10.1111/j.1471-0528.2007.01385.x
RCOG 2007 BJOG An International Journal of Obstetrics and Gynaecology
Issue
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 114, Issue 7, pages 796–801, July 2007
Additional Information
How to Cite
Trochez-Martinez, R., Smith, P. and Lamont, R. (2007), Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology, 114: 796–801. doi: 10.1111/j.1471-0528.2007.01385.x
Publication History
- Issue published online: 12 JUN 2007
- Article first published online: 12 JUN 2007
- Accepted 29 March 2007.
- Abstract
- Article
- References
- Cited By
Keywords:
- C-reactive protein;
- chorioamnionitis;
- preterm prelabour rupture of membranes
Background Studies examining the use of C-reactive protein (CRP) as a predictor of chorioamnionitis in preterm prelabour rupture of membranes (PPROM) report highly conflicting results. Despite this, CRP is commonly used for the early diagnosis of chorioamnionitis.
Objective To determine the diagnostic accuracy of CRP in the detection of chorioamnionitis in women with PPROM.
Design Systematic review.
Search strategy Studies were identified from MEDLINE (1966–2006), EMBASE (1974–2006), PubMed and the Cochrane Library (2005) and from reference lists from primary studies and reviews.
Selection criteria Only studies of good methodological quality that evaluated the diagnostic performance of CRP in chorioamnionitis in women with PPROM were selected.
Data collection and analysis Positive and negative likelihood ratios (LR) and diagnostic odds ratios (DOR) were calculated. An attempt was made at pooling data for meta-analysis, but this was considered inappropriate due to the significant unexplained heterogeneity between studies.
Main results There were eight primary studies comprising 610 cases which met the inclusion criteria. There was wide variation in the positive and negative LR and DOR between the studies, with significant lack of precision demonstrated by wide confidence intervals. Three of the studies concluded that CRP was a useful diagnostic tool for chorioamnionitis (DOR ranging from 4.2 to 191.6), although one of them suggested a higher CRP threshold. The other five studies concluded the opposite (DOR ranging from 1.4 to 17.7).
Author’s conclusions There is no clear evidence to support the use of CRP for the early diagnosis of chorioamnionitis. Further research is required to address the contradictory findings of diagnostic accuracy.