• 1
    HMSO. Report on Confidential Enquiries into Maternal Deaths in the United Kingdom 1988-1990. Department of Health Welsh Office, Scottish Office Home and Health Department, Department of Health and Social Security, Northern Ireland. London: HMSO, 1994.
  • 2
    NHMRC. Report on Maternal Deaths in Australia 1988-1990. Canberra, Australia: Government Publishing Service, 1993.
  • 3
    Villar J, Say L, Shennan A, Lindheimer M, Duley L, Conde-Agudelo A, et al. Methodological and technical issues related to the diagnosis, screening, prevention and treatment of pre-eclampsia and eclampsia. Int J Gynaecol Obstet 2004;85:S28S41.
  • 4
    Carroli G, Duley L, Belizan JM, Villar J. Calcium supplementation during pregnancy: a systematic review of randomised controlled trials. Br J Obstet Gynaecol 1994;101:7538.
  • 5
    Bucher HC, Guyatt GH, Cook RJ, Hatala R, Cook DJ, Lang JD, et al. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA 1996;275:11137.
  • 6
    CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant woman. Lancet 1994;343:61929.
  • 7
    ECPPA (Estudo Collaborativo para Prevenção da Pre-eclampsia com Aspirina) Collaborative Group. ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant woman. Br J Obstet Gynaecol 1996;103:3947.
  • 8
    Yamasmit W, Chaithongwongwatthana S, Charoenvidhya D, Uerpairojkit B, Tolosa J. Random urinary protein-to-creatinine ratio for prediction of significant proteinuria in women with preeclamsia. J Matern Fetal Neonatal Med 2004;16:2759.
  • 9
    Von Dadelszen P, Magee LA, Devarakonda RM, Hamiltom T, Ainsworth LM, Yin R, et al. The prediction of adverse maternal outcomes in pre-eclampsia. J Obstet Gynaecol Can 2004;26:8719.
  • 10
    Belizan JM, Villar J. The relationship between calcium intake and edema, proteinuria, and hypertension-gestosis: an hypothesis. Am J Clin Nutr 1980;33:220210.
  • 11
    Hamlin RHJ. Prevention of pre-eclampsia. Lancet 1962;1:8645.
  • 12
    Hamlin RHJ. The prevention of eclampsia and pre-eclampsia. Lancet 1952;i:648.
  • 13
    Villar J, Belizan JM, Fischer PJ. Epidemiologic observations on the relationship between calcium intake and eclampsia. Int J Gynaecol Obstet 1983;21:2718.
  • 14
    Belizan JM, Villar J, Repke J. The relationship between calcium intake and pregnancy-induced hypertension: up-to-date evidence. Am J Obstet Gynecol 1988;158:898902.
  • 15
    Repke JT, Villar J. Pregnancy-induced hypertension and low birth weight: the role of calcium. Am J Clin Nutr 1991;54:237S41S.
  • 16
    Villar J, Repke J, Belizan JM, Pareja G. Calcium supplementation reduces blood pressure during pregnancy: results of a randomized controlled clinical trial. Obstet Gynecol 1987;70:31722.
  • 17
    Segovia BL, Vega IT, Villarreal EC, Licona NA. Hypocalciuria during pregnancy as a risk factor of preeclampsia. Ginecol Obstet Mex 2004;72:5704.
  • 18
    Kazerooni T, Hamze-Nejadi S. Calcium to creatinine ratio in a spot sample of urine for early prediction of pre-eclampsia. Int J Gynaecol Obstet 2003;80:27983.
  • 19
    Kumru S, Aydin S, Simsek M, Sahin K, Yaman M, Ay G. Comparison of serum copper, zinc, calcium, and magnesium levels in preeclamptic and healthy pregnant women. Biol Trace Elem Res 2003;94:10512.
  • 20
    Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular, and plasma magnesium and calcium concentrations in preeclampsia. Am J Hypertens 2000;13:7659.
  • 21
    Duvekot EJ, De Groot CJ, Bloemenkamp KW, Oei SG. Pregnant women with a low milk intake have an increased risk of developing preeclampsia. Eur J Obstet Gynecol Reprod Biol 2002;105:1114.
  • 22
    Isezuo SA, Ekele BA. Eclampsia and abnormal QTc. West Afr J Med 2004;23:1237.
  • 23
    Villar J, Belizan JM, Repke J. The effect of calcium supplementation on the incidence of hypertensive disorders of pregnancy and prematurity. 7th World Congress of Hypertension in Pregnancy; 1990; Perugia, Italy. 1990;54.
  • 24
    Repke JT, Villar J, Anderson C, Pareja G, Dubin N, Belizan JM. Biochemical changes associated with blood pressure reduction induced by calcium supplementation during pregnancy. Am J Obstet Gynecol 1989;160:68490.
  • 25
    Duley L. Routine calcium supplementation in pregnancy. In: EnkinMW, KeirseMJNC, RenfrewMJ, NeilsonJP, CrowtherC, editors. Pregnancy and Childbirth Module. The Cochrane Pregnancy and Childbirth Database. The Cochrane Collaboration; Issue 2. Oxford: Update Software; 1995.
  • 26
    Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1997;337:6976.
  • 27
    DerSimonian R, Levine RJ. Resolving discrepancies between a meta-analysis and a subsequent large controlled trial. JAMA 1999;282:66470.
  • 28
    Villar J, Abdel-Aleem H, Merialdi M, Mathai M, Ali M, Zavaleta N, et al. World Health Organisation randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol 2006;194:63949.
  • 29
    Hofmeyr GJ, Duley L, Atallah AN. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2006;3:CD001059.
  • 30
    Pregnancy and Childbirth Group. Search strategies for identification of studies. Cochrane Database Syst Rev 2005;1:PREG.
  • 31
    Review Manager (RevMan). 4.1 for Windows Edition. Oxford, UK: The Cochrane Collaboration, 2000.
  • 32
    Greenland S. Invited commentary: a critical look at some popular meta-analytic methods. Am J Epidemiol 1994;140:2906.
  • 33
    Villar J, Carroli G, Belizan JM. Predictive ability of meta-analysis of randomised control trials. Lancet 1995;345:7726.
  • 34
    Early Breast Cancer Trialists’ Collaborative Statistical methods. Treatment of Early Breast Cancer: Vol. 1. Worldwide Evidence 1985-1990. Oxford, UK: Oxford University Press, 1990. pp. 1318.
  • 35
    Belizan JM, Villar J, Gonzalez L, Campodonico L, Bergel E. Calcium supplementation to prevent hypertensive disorders of pregnancy. N Engl J Med 1991;325:1399405.
  • 36
    Lopez-Jaramillo P, Narvaez M, Weigel RM, Yepez R. Calcium supplementation reduces the risk of pregnancy-induced hypertension in an Andes population. Br J Obstet Gynaecol 1989;96:64855.
  • 37
    Villar J, Repke JT. Calcium supplementation during pregnancy may reduce preterm delivery in high-risk populations. Am J Obstet Gynecol 1990;163:112431.
  • 38
    Lopez-Jaramillo P, Narvaez M, Felix C, Lopez A. Dietary calcium supplementation and prevention of pregnancy hypertension. Lancet 1990;335:293.
  • 39
    Sanchez-Ramos L, Briones DK, Kaunitz AM, Delvalle GO, Gaudier FL, Walker KD. Prevention of pregnancy-induced hypertension by calcium supplementation in angiotensin II-sensitive patients. Obstet Gynecol 1994;84:34953.
  • 40
    Purwar M, Kulkarni H, Motghare V, Dhole S. Calcium supplementation and prevention of pregnancy induced hypertension. J Obstet Gynaecol Res 1996;22:42530.
  • 41
    Lopez-Jaramillo P, Delgado F, Jacome P, Teran E, Ruano C, Rivera J. Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers. Obstet Gynecol 1997;90:1627.
  • 42
    Crowther CA, Hiller JE, Pridmore B, Bryce R, Duggan P, Hague WM, et al. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. Aust N Z J Obstet Gynaecol 1999;39:1218.
  • 43
    Niromanesh S, Laghaii S, Mosavi-Jarrahi A. Supplementary calcium in prevention of pre-eclampsia. Int J Gynaecol Obstet 2001;74:17–21.
  • 44
    Belizan JM, Villar J, Bergel E, Del Pino A, Di Fulvio S, Galliano SV, et al. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ 1997;315:2815.
  • 45
    Hatton DC, Harrison-Hohner J, Coste S, Reller M, McCarron D. Gestational calcium supplementation and blood pressure in the offspring. Am J Hypertens 2003;16:8015.
  • 46
    McGarvey ST, Zinner SH, Willett WC, Rosner B. Maternal prenatal dietary potassium, calcium, magnesium and infant blood pressure. Hypertension 1991;17:21824.
  • 47
    Bergel E, Belizan JM. A deficient maternal calcium intake during pregnancy increases blood pressure of the offspring in adult rats. BJOG 2002;109:5405.