Local inflammatory response in choriodecidua induced by Ureaplasma urealyticum

Authors

  • R Aaltonen,

    Corresponding author
    1. a Department of Obstetrics and Gynecology, Turku University Hospital, b Department of Medical Microbiology and c Department of Biostatistics, University of Turku, Turku, Finlandd Statens Serum Institut, Copenhagen, Denmark
      Dr R Aaltonen, Department of Obstetrics and Gynecology, University of Turku, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland. Email riikka.aaltonen@tyks.fi
    Search for more papers by this author
  • a,b J Heikkinen,

    1. a Department of Obstetrics and Gynecology, Turku University Hospital, b Department of Medical Microbiology and c Department of Biostatistics, University of Turku, Turku, Finlandd Statens Serum Institut, Copenhagen, Denmark
    Search for more papers by this author
  • b T Vahlberg,

    1. a Department of Obstetrics and Gynecology, Turku University Hospital, b Department of Medical Microbiology and c Department of Biostatistics, University of Turku, Turku, Finlandd Statens Serum Institut, Copenhagen, Denmark
    Search for more papers by this author
  • c JS Jensen,

    1. a Department of Obstetrics and Gynecology, Turku University Hospital, b Department of Medical Microbiology and c Department of Biostatistics, University of Turku, Turku, Finlandd Statens Serum Institut, Copenhagen, Denmark
    Search for more papers by this author
  • and d A Alanen a

    1. a Department of Obstetrics and Gynecology, Turku University Hospital, b Department of Medical Microbiology and c Department of Biostatistics, University of Turku, Turku, Finlandd Statens Serum Institut, Copenhagen, Denmark
    Search for more papers by this author

Dr R Aaltonen, Department of Obstetrics and Gynecology, University of Turku, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland. Email riikka.aaltonen@tyks.fi

Abstract

Ureaplasma urealyticum is the bacterial species most often connected with preterm birth, although it often colonises the amniotic fluid without any adverse effects. The induction of preterm labour seems to depend on whether the bacteria produce an inflammatory reaction. In vitro stimulation of choriodecidual tissue with high amounts of U.urealyticum or with lipopolysaccharide induced a qualitatively similar inflammatory response detected by the production of tumour necrosis factor alpha, followed by secretion of anti-inflammatory cytokine interleukin-10 and of prostaglandin E2. Lower quantities of bacteria failed to induce any response.

Ancillary