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An introduction to Toll-like receptors and their possible role in the initiation of labour
Article first published online: 28 SEP 2007
DOI: 10.1111/j.1471-0528.2007.01488.x
RCOG 2007 BJOG An International Journal of Obstetrics and Gynaecology
Issue
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 114, Issue 11, pages 1326–1334, November 2007
Additional Information
How to Cite
Patni, S., Flynn, P., Wynen, L., Seager, A., Morgan, G., White, J. and Thornton, C. (2007), An introduction to Toll-like receptors and their possible role in the initiation of labour. BJOG: An International Journal of Obstetrics & Gynaecology, 114: 1326–1334. doi: 10.1111/j.1471-0528.2007.01488.x
Publication History
- Issue published online: 28 SEP 2007
- Article first published online: 28 SEP 2007
- Accepted 9 July 2007. Published OnlineEarly 28 September 2007.
- Abstract
- Article
- References
- Cited By
Keywords:
- Cytokines;
- human;
- parturition;
- preterm;
- toll-like receptors
Toll-like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the process of parturition suggesting that TLR activity within gestation-associated tissues might have an important role in the initiation and/or maintenance of normal term labour and in various pathological states of pregnancy such as infection-associated preterm labour. Either TLRs or their signalling molecules might be excellent therapeutic targets for prevention of preterm labour.