Is adiposity across life associated with subsequent hysterectomy risk? Findings from the 1946 British birth cohort study
Article first published online: 7 DEC 2007
RCOG 2008 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Special Issue: Health of women and babies: long-term and intergenerational perspectives
Volume 115, Issue 2, pages 184–192, January 2008
How to Cite
Cooper, R., Hardy, R. and Kuh, D. (2008), Is adiposity across life associated with subsequent hysterectomy risk? Findings from the 1946 British birth cohort study. BJOG: An International Journal of Obstetrics & Gynaecology, 115: 184–192. doi: 10.1111/j.1471-0528.2007.01569.x
- Issue published online: 7 DEC 2007
- Article first published online: 7 DEC 2007
- Accepted 23 August 2007.
- Birth cohort study;
- body mass index;
- life course
Objective To examine the associations between adiposity at time points from early life onwards and subsequent hysterectomy risk.
Design Prospective birth cohort study.
Setting England, Scotland and Wales.
Population Women from the Medical Research Council National Survey of Health and Development study, with complete data on hysterectomy status (n= 1790).
Methods Survival analysis methods were used to examine the associations between body mass index at time points across life and subsequent hysterectomy rates.
Main outcome measure Self-reported hysterectomy with or without oophorectomy.
Results From 20 years onwards, those women who were classified as underweight had lower hysterectomy rates, and from 36 years onwards, those women who were overweight had higher hysterectomy rates than those who were normal weight. Women who were obese in adolescence and early adulthood had lower rates of hysterectomy than those who were normal weight, although numbers categorised as obese at these ages were small. Women who were obese in later adulthood had higher subsequent rates of hysterectomy. Greater increases in weight between ages 36 and 53 years were associated with higher rates of hysterectomy in later adulthood. These results were not explained by parity, age at menarche or socio-economic position.
Conclusions These results suggest that variation in hysterectomy rates may be partially explained by variation in adiposity, and so with the recent changes in levels of overweight and obesity in populations, there may be increasing demand for gynaecological treatments in the future.