Review article: Developmental mismatch: consequences for later cardiorespiratory health
Article first published online: 7 DEC 2007
RCOG 2008 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Special Issue: Health of women and babies: long-term and intergenerational perspectives
Volume 115, Issue 2, pages 149–157, January 2008
How to Cite
Pike, K., Hanson, M. and Godfrey, K. (2008), Review article: Developmental mismatch: consequences for later cardiorespiratory health. BJOG: An International Journal of Obstetrics & Gynaecology, 115: 149–157. doi: 10.1111/j.1471-0528.2007.01603.x
- Issue published online: 7 DEC 2007
- Article first published online: 7 DEC 2007
- Accepted 19 October 2007.
- Cardiovascular disease;
- fetal growth;
- maternal nutrition;
- respiratory disease
Clinical and epidemiological studies have established that people who were small at birth and had poor infant growth have an increased risk of adult cardiovascular and respiratory disease, particularly if their restricted early growth is followed by accelerated childhood weight gain. This relationship extends across the normal range of infant size in a graded manner. The ‘mismatch hypothesis’ proposes that ill health in later life originates through developmental plastic responses made by the fetus and infant; these responses increase the risk of adult disease if the environment in childhood and adult life differs from that predicted during early development.