Pre-eclampsia is associated with airway hyperresponsiveness
Article first published online: 16 JAN 2008
2008 The Authors Journal compilation
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 115, Issue 4, pages 520–522, March 2008
How to Cite
Siddiqui, S., Goodman, N., McKenna, S., Goldie, M., Waugh, J. and Brightling, C. (2008), Pre-eclampsia is associated with airway hyperresponsiveness. BJOG: An International Journal of Obstetrics & Gynaecology, 115: 520–522. doi: 10.1111/j.1471-0528.2007.01623.x
- Issue published online: 6 FEB 2008
- Article first published online: 16 JAN 2008
- Accepted 8 November 2007. Published OnlineEarly 16 January 2008.
- Airway hyperresponsiveness;
- mast cell;
Several large retrospective cohort studies demonstrate that pre-eclampsia is common in asthmatics. Whether airway hyperresponsiveness (AHR), a hallmark of asthma, is associated with pre-eclampsia is unknown. We measured AHR, using a methacholine challenge, and atopy in 19 women 3–60 months postpartum following pre-eclamptic or normotensive pregnancies. The geometric mean (95% CI) concentration of methacholine required to produce a >20% fall in the forced expiratory volume in 1 second (PC20 FEV1) was 8.9 (2.2–36) mg/ml in pre-eclamptics versus 72 (32–131) mg/ml in controls (P = 0.01) and 9 (1.9–40) mg/ml in atopic pre-eclamptics without asthma versus 54 (17–174) mg/ml (P = 0.038) in matched controls. Therefore, AHR was increased in women who have had pre-eclampsia. This association and its possible mechanisms warrant further investigation.