• Open Access

Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for neural tube defects and Down’s syndrome

Authors


  • *

    Martin Haeusler (Austria), Yves Gillerot (Belgium), Ingeborg Barisic (Croatia), Marianne Christiansen (Denmark), Annukka Ritvanen (Finland), Annette Queisser-Luft (Germany), Bob McDonnell (Republic of Ireland), Eliza Calzolari (Italy), Miriam Gatt (Malta), Hermien de Walle (Netherlands), Lorentz Irgens (Norway), Anna Latos-Bielenska (Poland), Maria Feijoo (Portugal), Isabel Portillo (Spain), Birgitta Ollars (Sweden), Marie-Claude Addor (Switzerland) and David Tucker (Wales).

  • Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

Dr PA Boyd, National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK. Email patricia.boyd@npeu.ox.ac.uk

Abstract

Objective  To ‘map’ the current (2004) state of prenatal screening in Europe.

Design  (i) Survey of country policies and (ii) analysis of data from EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers.

Setting  Europe.

Population  Survey of prenatal screening policies in 18 countries and 1.13 million births in 12 countries in 2002–04.

Methods  (i) Questionnaire on national screening policies and termination of pregnancy for fetal anomaly (TOPFA) laws in 2004. (ii) Analysis of data on prenatal detection and termination for Down’s syndrome and neural tube defects (NTDs) using the EUROCAT database.

Main outcome measures  Existence of national prenatal screening policies, legal gestation limit for TOPFA, prenatal detection and termination rates for Down’s syndrome and NTD.

Results  Ten of the 18 countries had a national country-wide policy for Down’s syndrome screening and 14/18 for structural anomaly scanning. Sixty-eight percent of Down’s syndrome cases (range 0–95%) were detected prenatally, of which 88% resulted in termination of pregnancy. Eighty-eight percent (range 25–94%) of cases of NTD were prenatally detected, of which 88% resulted in termination. Countries with a first-trimester screening policy had the highest proportion of prenatally diagnosed Down’s syndrome cases. Countries with no official national Down’s syndrome screening or structural anomaly scan policy had the lowest proportion of prenatally diagnosed Down’s syndrome and NTD cases. Six of the 18 countries had a legal gestational age limit for TOPFA, and in two countries, termination of pregnancy was illegal at any gestation.

Conclusions  There are large differences in screening policies between countries in Europe. These, as well as organisational and cultural factors, are associated with wide country variation in prenatal detection rates for Down’s syndrome and NTD.

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