The effect of hyoscine butyl bromide on the first stage of labour in term pregnancies
Article first published online: 28 JUN 2008
© 2008 The Author Journal compilation © RCOG 2008 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 115, Issue 8, page 1064, July 2008
How to Cite
Raghavan, R. (2008), The effect of hyoscine butyl bromide on the first stage of labour in term pregnancies. BJOG: An International Journal of Obstetrics & Gynaecology, 115: 1064. doi: 10.1111/j.1471-0528.2008.01760.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Accepted 5 March 2008.
I read with interest the article by Samuels et al.1 on the effect of hyoscine butyl bromide on the first stage of labour in term pregnancies. I have also studied the effects of hyoscine butyl bromide and my conclusions were similar. However in addition, I studied the effects of valethamate bromide on the first stage of labour. My study was a randomised, double-blinded, controlled trial involving primigravidae in spontaneous labour at term with singleton pregnancies and no clinical cephalopelvic disproportion. This study was conducted at the Vani Vilas Hospital, Bangalore, India, from March to December 2002, with approval from the Hospital ethics committee. We recruited 150 women to the study and randomised 50 women to receive hyoscine butyl bromide, 50 women to receive valethamate bromide and 50 women to the control group. Both these drugs are parasympatholytic drugs and are approved for use in the augmentation of the first stage of labour. Valethamate bromide has been shown to be effective due to its vagolytic activity and effect on cervical dilatation.2,3 Hyoscine has been found to be effective when administered rectally and this route was used in our study.4 Interestingly, our subjects found this more acceptable than the intravenous valethamate bromide. The parameters studied in our trial were total duration of labour, rate of cervical dilatation, percentage of cases delivered before eight hours, complications for the mother, and neonatal effects. All the women were aged between 18 and 32 years and were comparable with respect to the demographic variables studied. The mean duration of first stage was 11.19 hours in the control group, 7.73 hours in the valethamate bromide group and 7.03 hours in the hyoscine group. There was a significant reduction in the duration of first stage of labour (and hence the total duration of labour) in the study groups compared with the controls. No significant effect on the mode of delivery was noted. Mild adverse effects, such as tachycardia, dryness of mouth and vomiting were noted in the both drug groups. No significant complications of labour or neonatal effects were noted in any of the groups.
The conclusion of our study was that both hyoscine butyl bromide and valethamate bromide are effective in acceleration of first stage of labour. I wonder if Dr Samuel’s team have any experience with the valethamate bromide?
- 2Effect of intravenous infusion of epidosin on labour. J Obstet Gynaecol Ind 1995;45:798–810., , .
- 3Effect of epidosin on cervical dilatation during labour. J Obstet Gynaecol Ind 1998;38:427–30., , .
- 4Hyoscine-n-butyl bromide in acceleration of labour. J Obstet Gynaecol Ind 1984;34:509., , , .