The hidden mortality of transposition of the great arteries and survival advantage provided by prenatal diagnosis
Article first published online: 2 JUN 2008
© 2008 Authors Journal compilation © RCOG 2008 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 115, Issue 9, pages 1096–1100, August 2008
How to Cite
Blyth, M., Howe, D., Gnanapragasam, J. and Wellesley, D. (2008), The hidden mortality of transposition of the great arteries and survival advantage provided by prenatal diagnosis. BJOG: An International Journal of Obstetrics & Gynaecology, 115: 1096–1100. doi: 10.1111/j.1471-0528.2008.01793.x
- Issue published online: 14 JUL 2008
- Article first published online: 2 JUN 2008
- Accepted 21 April 2008. Published OnlineEarly 2 June 2008.
- Fetal echocardiography;
- prenatal diagnosis;
- transposition of the great arteries
Objective To describe the sensitivity of fetal anomaly scanning at detecting transposition of the great arteries (TGA) and to investigate whether prenatal detection improves survival.
Design Retrospective review of survival by comparing those who had an antenatal diagnosis with those who did not.
Setting Population-based study in Wessex region over 13 years.
Population Babies with isolated TGA and an intact ventricular septum.
Methods Review of outcomes by comparing those who had an antenatal diagnosis with those who did not.
Main outcome measures Mortality rates in each group.
Results TGA occurred more commonly in boys than in girls. Using the existing national screening policy, the antenatal detection rate of TGA was only 6.9% over the study period, improving to 25% in the last 4 years. This contrasts with a 40% detection rate when TGA was associated with a ventricular septal defect (VSD). All the babies who had TGA diagnosed antenatally survived through surgery. Of those who were not diagnosed antenatally, two were stillborn, five died before the diagnosis was made and four died after surgery. Although the difference in survival rates between those who were antenatally diagnosed and those who were not is not statistically significant (χ2= 3.9; P = 0.11), some of these deaths could have been prevented if a prenatal diagnosis had been made.
Conclusions Improved antenatal diagnosis could lead to a significant reduction in the mortality associated with TGA. The current low detection rate of TGA in the UK could be improved by the inclusion of outflow tract views in routine fetal anomaly scans, and we believe that the extra workload is justified.