• Endometrial biopsy;
  • H Pipelle;
  • ‘no-touch’ hysteroscopy;
  • Pipelle de Cornier;
  • vaginoscopic hysteroscopy

Objectives  To evaluate the effectiveness and tolerance of H Pipelle compared with the standard Pipelle as an endometrial biopsy device at outpatient ‘no-touch’ hysteroscopy.

Design  A prospective randomised trial carried out in an outpatient diagnostic hysteroscopy clinic.

Setting  A large undergraduate teaching hospital.

Population  Sixty women investigated for abnormal menstruation in an outpatient diagnostic hysteroscopy clinic.

Methods  Prospective randomised trial comparing the H Pipelle with the standard Pipelle de Cornier.

Main outcome measures  Adequacy of the biopsy specimens and women’s experience.

Results  Ninety-three percent (H Pipelle) and 87% (Pipelle) of the biopsy specimens were judged to be adequate for histological diagnosis (P > 0.05). However, obtaining endometrial sampling with the H Pipelle was significantly quicker (median times: 39 seconds [H Pipelle] and 102 seconds [Pipelle], P < 0.0001) and less painful (median visual analogue scale score: 1 [H Pipelle] and 5 [Pipelle], P = 0.011).

Conclusions  The H Pipelle not only makes it possible to perform hysteroscopy and endometrial biopsy with minimal instrumentation but is also associated with a shorter biopsy time and less discomfort than the standard Pipelle without any loss of biopsy adequacy.