US7447542: A US patent was granted in November 2008 for a system using an electromyogram, incorporating position sensors to enable three-dimensional monitoring of myographic activity in muscles, such as the contracting uterus during labour. This invention aims to improve monitoring of uterine activity by assessing the effectiveness of contractions. It also aims to help prevent premature birth as well as research generally in obstetrics and gynaecology settings.
Calderon I, Ben-David G. Three-dimensional monitoring of myographic activity.
The potential benefits of a device that might be able to improve the accuracy of measuring uterine activity noninvasively, particularly if it can more reliably predict preterm labour, are considerable.
US7445621: This patent, granted in November 2008, relates to an instrument that combines the benefits of both monopolar and bipolar endoscopic coagulating forceps, reducing the need for surgeons to change instruments during certain surgical procedures. The forceps have been modified to include a shaft fitted with moveable jaws and a connector to enable each of the jaws to be connected to an electrical source. This allows the jaws to operate in a bipolar mode conducting electricity through tissue to coagulate, seal or cut the tissue. The forceps can also be used in monopolar mode independent of the bipolar mode. This invention is a continuation of patent number US7232440.
Dumbauld PL, Garrison DM, Guerra P, Peterson D, Dycus ST. Bi-polar forceps having monopolar extension.
WO2008/132153 A1: This invention relates to novel tetrahydrocarbazole derivatives that act as ligands of G-protein-coupled receptors (GPCRs), but especially as antagonists of luteinizing hormone-releasing hormone. These compounds could be used to prevent or treat physiological or pathological conditions, which are mediated or modulated by GPCRs, such as gynaecological cancers, endometriosis and uterine fibroids.
Schuster T, Paulini K, Schmidt P, Baasner S, Polymeropoulos E, Günther E, Teifel M. Novel tetrahydrocarbazole derivatives as ligands of G-protein coupled receptors.
GPCRs represent a superfamily of cell membrane-associated receptors that play an important part in numerous biochemical processes. They mediate and control diverse physiological stimuli, such as photosensitivity, taste and smell, as well as fundamental processes, such as metabolism, reproduction and development. Peptide hormones, biogenic amines, amino acids, nucleotides and lipids have been identified as ligands.
Tetrahydrocarbazole carboxylic acids have previously been described as prostaglandin antagonists and 5HT1 agonists; however, their use for this indication is novel.
US2008/0275363 A1: This patent application relates to an instrument for examining the wall of a body cavity, in particular the uterus, which includes a catheter through which fluid can be inserted into the cavity, an outflow opening, a sealing element (preferably a cervix cone) to prevent leakage of the fluid from the cavity, a gripping attachment for ease of use and a vacuum.
Schoot BC. Device and Method for Examination of a Body Cavity.
The simplicity of this invention compared with previously proposed, more complex devices and its similar mode of action to the microsuction curette may improve its acceptability.
US2008/0275026 A1: This patent application relates to the use of novel nonpeptide oxytocin agonists and vasopressin antagonists in pharmaceutical compounds for treating a range of conditions including primary dysmenorrhoea. Currently, only one oxytocin receptor has been well researched and only three vasopressin receptors are known. Peptide analogues of oxytocin are well known, but little has been reported on nonpeptide oxytocin receptor agonists, which have the advantage over peptide versions of oral administration (as well as penetration of the central nervous system). High levels of vasopressin have been found in women with dysmenorrhoea, and it is hoped that by reducing the stimulation of V1A receptors, vasopressin antagonists would reduce the symptoms. This application is a division of patent number US7407949.
Hudson P, Batt AR, Heeney CM, Baxter AJ, Roe MB, Robson PA. Benzamide derivatives as oxytocin agonists and vasopressin antagonists.
There is currently a surge of interest in this area: we reported in a previous issue (December 2008) on a patent application for triazole antagonists, which may be useful as vasopressin antagonists.