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Complications during pregnancy in women with epilepsy: population-based cohort study

  1. I Borthen1,2,
  2. MG Eide2,
  3. G Veiby1,5,
  4. AK Daltveit3,4,
  5. NE Gilhus1,5

Article first published online: 23 SEP 2009

DOI: 10.1111/j.1471-0528.2009.02354.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 116, Issue 13, pages 1736–1742, December 2009

Additional Information

How to Cite

Borthen, I., Eide, M., Veiby, G., Daltveit, A. and Gilhus, N. (2009), Complications during pregnancy in women with epilepsy: population-based cohort study. BJOG: An International Journal of Obstetrics & Gynaecology, 116: 1736–1742. doi: 10.1111/j.1471-0528.2009.02354.x

Author Information

  1. 1

    Department of Clinical Medicine, University of Bergen, Bergen, Norway

  2. 2

    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway

  3. 3

    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway

  4. 4

    Medical Birth Registry of Norway, Norwegian Institute of Public Health, Bergen, Norway

  5. 5

    Department of Neurology, Haukeland University Hospital, Bergen, Norway

*Dr I Borthen, Department of Gynecology and Obstetrics, Haukeland University Hospital, N-5021 Bergen, Norway. Email ingrid.borthen@med.uib.no

Publication History

  1. Issue published online: 11 NOV 2009
  2. Article first published online: 23 SEP 2009
  3. Accepted 22 July 2009. Published Online 23 September 2009.

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References

  • 1
    Richmond JR, Krishnamoorthy P, Andermann E, Benjamin A. Epilepsy and pregnancy: an obstetric perspective. Am J Obstet Gynecol 2004;190:371–9.
  • 2
    Olafsson E, Hallgrimsson JT, Hauser WA, Ludvigsson P, Gudmundsson G. Pregnancies of women with epilepsy: a population-based study in Iceland. Epilepsia 1998;39:887–92.
    Direct Link:
  • 3
    AAN Quality Standards Subcommittee. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 1998;51:944–8.
  • 4
    Viinikainen K, Heinonen S, Eriksson K, Kalviainen R. Community-based, prospective, controlled study of obstetric and neonatal outcome of 179 pregnancies in women with epilepsy. Epilepsia 2006;47:186–92.
    Direct Link:
  • 5
    Yerby MS, Kaplan P, Tran T. Risks and management of pregnancy in women with epilepsy. Cleve Clin J Med 2004;71(Suppl. 2):S25–37.
  • 6
    Zahn C. Neurologic care of pregnant women with epilepsy. Epilepsia 1998;39(Suppl. 8):S26–31.
    Direct Link:
  • 7
    Bjerkedal T, Bahna SL. The course and outcome of pregnancy in women with epilepsy. Acta Obstet Gynecol Scand 1973;52:245–8.
  • 8
    Crawford P. Best practice guidelines for the management of women with epilepsy. Epilepsia 2005;46(Suppl. 9):117–24.
    Direct Link:
  • 9
    Cunningham FGMP, Gant NF, Leveno KJ, Gilstrap LC, Hankins GDV, Clark SL. Neurological and Psychiatric Disorders. Williams Obstetrics, 20th edn. Stamford: Appleton and Lange, 1997; 1256–7.
  • 10
    Yerby M, Koepsell T, Daling J. Pregnancy complications and outcomes in a cohort of women with epilepsy. Epilepsia 1985;26:631–5.
    Direct Link:
  • 11
    Thomas SV, Sindhu K, Ajaykumar B, Devi PB, Sujamol J. Maternal and obstetric outcome of women with epilepsy. Seizure 2009;18:163–6.
  • 12
    Fairgrieve SD, Jackson M, Jonas P, Walshaw D, White K, Montgomery TL, et al. Population based, prospective study of the care of women with epilepsy in pregnancy. BMJ 2000;321:674–5.
  • 13
    Hiilesmaa VK, Bardy A, Teramo K. Obstetric outcome in women with epilepsy. Am J Obstet Gynecol 1985;152:499–504.
  • 14
    Katz O, Levy A, Wiznitzer A, Sheiner E. Pregnancy and perinatal outcome in epileptic women: a population-based study. J Matern Fetal Neonatal Med 2006;19:21–5.
  • 15
    Kaplan PW, Norwitz ER, Ben-Menachem E, Pennell PB, Druzin M, Robinson JN, et al. Obstetric risks for women with epilepsy during pregnancy. Epilepsy Behav 2007;11:283–91.
  • 16
    Pilo C, Wide K, Winbladh B. Pregnancy, delivery, and neonatal complications after treatment with antiepileptic drugs. Acta Obstet Gynecol Scand 2006;85:643–6.
  • 17
    Irgens LM. The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand 2000;79:435–9.
  • 18
    Backe B. Overutilization of antenatal care in Norway. Scand J Public Health 2001;29:129–32.
  • 19
    Skjaerven R, Vatten LJ, Wilcox AJ, Ronning T, Irgens LM, Lie RT. Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ 2005;331:877.
  • 20
    Rasmussen S, Irgens LM. Pregnancy-induced hypertension in women who were born small. Hypertension 2007;49:806–12.
  • 21
    Veiby G, Daltveit A, Engelsen Bernt, Gilhus NE. Prenancy, delivery and outcome for the child in maternal epilepsy. Epilepsia 2009 (in press).
    Direct Link:
  • 22
    Hoff JM, Daltveit AK, Gilhus NE. Myasthenia gravis in pregnancy and birth: identifying risk factors, optimising care. Eur J Neurol 2007;14:38–43.
    Direct Link:
  • 23
    Skomsvoll J, Ostensen M, Baste V, Irgens L. Validity of a rheumatic disease diagnosis in the Medical Birth Registry of Norway. Acta Obstet Gynecol Scand 2002;81:831–4.
    Direct Link:
  • 24
    Engeland A, Bramness JG, Daltveit AK, Ronning M, Skurtveit S, Furu K. Prescription drug use among fathers and mothers before and during pregnancy. A population-based cohort study of 106,000 pregnancies in Norway 2004–2006. Br J Clin Pharmacol 2008;65:653–60.
    Direct Link:
  • 25
    Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Risk factors and clinical manifestations of pre-eclampsia. BJOG 2000;107: 1410–6.
    Direct Link:
  • 26
    Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curet LB, et al. Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol 2000;95:24–8.
  • 27
    Donaldson JO. Neurological disorders. In: SwietMd, editor. Medical Disorders in Obstetric Practice, 4th edn. London: Blackwell Science Ltd; 2002. pp. 486–9.
  • 28
    Crawford P. Epilepsy and pregnancy. Seizure 2002;11(Suppl. A):212–9.
  • 29
    Tauboll E, Gjerstad L, Henriksen T, Husby H. [Pregnancy and birth in women with epilepsy]. Tidsskr Nor Laegeforen 2003;123:1695–7.
  • 30
    Kampman MT, Johansen SV, Stenvold H, Acharya G. Management of women with epilepsy: are guidelines being followed? Results from case-note reviews and a patient questionnaire. Epilepsia 2005; 46:1286–92.
    Direct Link:
  • 31
    Seale CG, Morrell MJ, Nelson L, Druzin ML. Analysis of prenatal and gestational care given to women with epilepsy. Neurology 1998;51: 1039–45.
  • 32
    Kaaja E, Kaaja R, Matila R, Hiilesmaa V. Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate. Neurology 2002;58:549–53.
  • 33
    NICE. Epilepsies, the Diagnosis and Management of the Epilepsies in Adults and Children in Primary and Secondary Care. Clinical Guideline 20 : London: NICE, 2004.
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