Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease

Authors


Dr KT Schmidt, The Fertility Clinic, Section 4071, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Email kirsten.tryde.schmidt@rh.regionh.dk

Abstract

Please cite this paper as: Schmidt K, Larsen E, Andersen C, Andersen A. Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease. BJOG 2010;117:163–174.

Girls and young women suffering from a malignant disease that requires treatment with chemo- and/or radiotherapy are at risk of losing fertility. The most significant risk factors are age and type of treatment given. Preserving fertility is of high priority to both the young patient and her parents. This article reviews the effect of chemo- and radiotherapy on gonadal function, and thus fertility, and offers different fertility preserving methods based on the literature. Cryopreservation of ovarian tissue is a possible way of preserving fertility in this group of patients in the future.

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