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Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia

  1. H Masuyama,
  2. T Segawa,
  3. Y Sumida,
  4. A Masumoto,
  5. S Inoue,
  6. Y Akahori,
  7. Y Hiramatsu

Article first published online: 10 DEC 2009

DOI: 10.1111/j.1471-0528.2009.02453.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 117, Issue 3, pages 314–320, February 2010

Additional Information

How to Cite

Masuyama, H., Segawa, T., Sumida, Y., Masumoto, A., Inoue, S., Akahori, Y. and Hiramatsu, Y. (2010), Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 314–320. doi: 10.1111/j.1471-0528.2009.02453.x

Author Information

  1. Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

*Dr H Masuyama, Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata, Okayama 700-8558, Japan. Email masuyama@cc.okayama-u.ac.jp

Publication History

  1. Issue published online: 12 JAN 2010
  2. Article first published online: 10 DEC 2009
  3. Accepted 22 October 2009. Published Online 9 December 2009.

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Keywords:

  • Adipocytokines;
  • angiogenic factor;
  • obesity;
  • pre-eclampsia

Please cite this paper as: Masuyama H, Segawa T, Sumida Y, Masumoto A, Inoue S, Akahori Y, Hiramatsu Y. Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia. BJOG 2010;117:314–320.

Objective  Circulating angiogenic factors have been shown to be important in the pathophysiology of pre-eclampsia. Blood levels of adipocytokines differ in pre-eclampsia relative to controls and may also play an important role in disease pathogenesis. Differences in the circulating levels of these molecules were compared between matched normotensive controls and women with pre-eclampsia with onset before or at/after 32 weeks, and according to whether the women were of normal weight (18.5 < body mass index < 25) or overweight.

Design  A cross-sectional study of 110 pregnant Japanese women who visited the Department of Obstetrics and Gynecology, Okayama University Hospital, Okayama, Japan.

Setting  Tertiary referral centre serving 2000 births.

Methods  Serum concentrations of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), soluble endoglin (sEng), adiponectin and leptin were measured in women with pre-eclampsia and in normotensive controls matched for age, gestational week, parity and body mass index.

Main outcome measures  Serum levels of sFlt-1, PlGF, the sFlt-1/PlGF ratio, sEng, adiponectin and leptin.

Results  The sFlt-1/PlGF ratio in early-onset pre-eclampsia was significantly higher than that in late-onset pre-eclampsia (112.0 ± 30.2 versus 45.4 ± 43.8, P = 0.037). There was a significant elevation of leptin in both subtypes relative to controls (early: 58.6 ± 18.3 ng/ml versus 26.0 ± 6.7 ng/ml, P = 0.001; late: 39.5 ± 9.2 ng/ml versus 22.0 ± 4.3 ng/ml, P = 0.005), but adiponectin was increased only in late-onset pre-eclampsia (36.5 ± 13.4 μg/ml versus 12.0 ± 4.3 μg/ml, P = 0.003). Significant differences in angiogenic factors and adiponectin were found between normal and overweight women only in late-onset pre-eclampsia.

Conclusions  These data suggest that there are different profiles of angiogenic factors and adipocytokines between women who develop early- and late-onset pre-eclampsia.

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