1471-0528/asset/BJO_left.gif?v=1&s=0fb87361cdb6be25fdf05019eed6d47f5143f610)
1471-0528/asset/olbannerright.gif?v=1&s=3892ef16ff18d6834c302faf85268a49f5fc588f)
Gynaecological oncology
A clinical review of borderline glandular cells reported on liquid-based cervical cytology
Article first published online: 26 JAN 2010
DOI: 10.1111/j.1471-0528.2009.02477.x
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
Issue
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 117, Issue 9, pages 1051–1059, August 2010
Additional Information
How to Cite
Patel, A., Thampy, N., Hemming, D. and Naik, R. (2010), A clinical review of borderline glandular cells reported on liquid-based cervical cytology. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 1051–1059. doi: 10.1111/j.1471-0528.2009.02477.x
Publication History
- Issue published online: 6 JUL 2010
- Article first published online: 26 JAN 2010
- Accepted 16 November 2009. Published Online 26 January 2010.
- Abstract
- Article
- References
- Cited By
Keywords:
- Atypical glandular cells of uncertain significance;
- borderline glandular cells;
- cervical cancer;
- intra-epithelial neoplasia;
- liquid based cytology
Please cite this paper as: Patel A, Thampy N, Hemming D, Naik R. A clinical review of borderline glandular cells reported on liquid-based cervical cytology. BJOG 2010;117:1051–1059.
Objective To review the clinical outcome of women presenting with borderline glandular cells on liquid-based cervical cytology (LBC).
Design Retrospective review.
Population and setting Women seen at a colposcopy clinic over a 26-month period referred with borderline glandular cells on LBC.
Methods Review of the case notes and cytology, pathology and colposcopy databases of all women referred with borderline glandular cells on LBC between June 2006 and August 2008.
Main outcome measures Final histological diagnosis.
Results Sixty-nine women were identified (0.19% of all smears). Twenty-seven women (39.1%) had premalignant or malignant lesions, five (7.2%) had cancers and 22 (31.9%) had intraepithelial neoplasia, 19 (27.5%) of which were cervical squamous intraepithelial neoplasia (CIN) and three (4.3%) of which were cervical glandular intraepithelial neoplasia (CGIN). No women under 35 years of age with normal and satisfactory colposcopy had premalignant or malignant lesions. Despite normal and satisfactory colposcopy, three women over 35 years had significant lesions: one high-grade CIN, one CGIN and one squamous cell carcinoma.
Conclusions On the basis of our results, it would be considered acceptable to manage women under 35 years of age with normal and satisfactory colposcopy conservatively. In women above 35 years of age, we would recommend a diagnostic ‘large loop excision of the transformation zone’ procedure, irrespective of the colposcopic findings.