Increased risk of low birthweight and small for gestational age infants among women with tuberculosis
Article first published online: 15 FEB 2010
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 117, Issue 5, pages 585–590, April 2010
How to Cite
Lin, H.-C., Lin, H.-C. and Chen, S.-F. (2010), Increased risk of low birthweight and small for gestational age infants among women with tuberculosis. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 585–590. doi: 10.1111/j.1471-0528.2010.02504.x
- Issue published online: 8 MAR 2010
- Article first published online: 15 FEB 2010
- Accepted 22 December 2009. Published Online 15 February 2010.
- Low birthweight;
- pregnancy outcome;
- small for gestational age;
Please cite this paper as: Lin H-C, Lin H-C, Chen S-F. Increased risk of low birthweight and small for gestational age infants among women with tuberculosis. BJOG 2010;117:585–590.
Objective As the relationship between tuberculosis (TB) and fetal outcomes remains unclear, this study used a 3-year nationwide population-based data set to determine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth and small for gestational age (SGA) infants] among women with TB.
Design A cross-sectional retrospective study.
Sample Linking the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset, we identified 761 women who gave birth from 2001 to 2003 and who had received medication treatment for TB during their pregnancy, together with 3805 unaffected women matched in terms of age and year of delivery.
Methods Conditional logistic regression analyses were performed to compare the risk of LBW, preterm birth and SGA for mothers with TB and unaffected mothers.
Main outcome measures The risk of LBW, preterm birth and SGA.
Results Mothers diagnosed with TB had significantly higher percentages of LBW (8.5 versus 6.4%, P = 0.033) and SGA (19.7 versus 16.7%, P = 0.048) infants than unaffected mothers. However, there was no significant difference in preterm birth (8.0 versus 8.0%, P = 0.961) between these two groups. The adjusted odds ratios of having LBW and SGA infants for mothers with TB were 1.35 (95% CI = 1.01–1.81) and 1.22 (95% CI = 1.00–1.49), respectively, compared with unaffected mothers.
Conclusions We concluded that women diagnosed with TB during pregnancy are at increased risk for having LBW and SGA babies, compared with unaffected mothers. We suggest that clinicians should make women with TB aware of the potential risks before planning a child.