Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes
Article first published online: 12 MAR 2010
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 117, Issue 6, pages 711–721, May 2010
How to Cite
Palomba, S., Falbo, A., Russo, T., Battista, L., Tolino, A., Orio, F. and Zullo, F. (2010), Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 711–721. doi: 10.1111/j.1471-0528.2010.02525.x
- Issue published online: 8 APR 2010
- Article first published online: 12 MAR 2010
- Accepted 24 January 2010.
- perinatal outcomes;
- pregnancy outcomes;
- uterine blood flow;
Please cite this paper as: Palomba S, Falbo A, Russo T, Battista L, Tolino A, Orio F, Zullo F. Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes. BJOG 2010; DOI: 10.1111/j.1471-0528.2010.02525.x.
Objective To study the impedance to blood flow through the uterine artery in pregnant women with polycystic ovary syndrome (PCOS), and to evaluate its predictive value for adverse pregnancy and perinatal outcomes in this population.
Design Prospective case-control study.
Setting Academic Departments of Obstetrics and Gynaecology in Italy.
Population Seventy-three pregnant women with ovulatory PCOS (PCOS group) and 73 age- and body mass index-matched healthy pregnant controls (control group).
Methods Serial Doppler velocimetry measurements of the uterine artery.
Main outcome measures Blood flow impedance indices and pregnancy/perinatal outcomes.
Results A significantly (P < 0.05) higher rate of subjects with abnormal velocimetry findings was observed in the PCOS group than in the control group. In the PCOS group, the pulsatility index (PI) at first (P = 0.042) and mid-second (P = 0.039) trimesters of pregnancy, and bilateral notch at first (P = 0.025) and mid-second (P = 0.007) trimesters of pregnancy, were the strongest independent predictors of adverse outcomes. Conversely, in the control group, PI at the first trimester of pregnancy was a predictor of adverse outcomes only when combined with bilateral notch (P = 0.042), whereas at mid-second trimester of pregnancy PI (P = 0.033) and bilateral notch (P = 0.048) were independent predictors of adverse outcomes.
Conclusions Uterine artery Doppler indices are more commonly altered in pregnant patients with PCOS than in controls, showing a high predictive value for abnormal pregnancy/perinatal outcomes.