Epidemiology

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Recurrence risk of stillbirth in a second pregnancy

  1. S Bhattacharya1,
  2. GJ Prescott2,
  3. M Black3,
  4. A Shetty4

Article first published online: 24 JUN 2010

DOI: 10.1111/j.1471-0528.2010.02641.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 117, Issue 10, pages 1243–1247, September 2010

Additional Information

How to Cite

Bhattacharya, S., Prescott, G., Black, M. and Shetty, A. (2010), Recurrence risk of stillbirth in a second pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 1243–1247. doi: 10.1111/j.1471-0528.2010.02641.x

Author Information

  1. 1

    Dugald Baird Centre for Research on Women’s Health, Aberdeen Maternity Hospital, Aberdeen, UK

  2. 2

    Medical Statistics Team, Section of Population Health, University of Aberdeen, Aberdeen, UK

  3. 3

    Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Aberdeen, UK

  4. 4

    Department of Obstetrics, Aberdeen Maternity Hospital, Aberdeen, UK

*Dr. S Bhattacharya, Dugald Baird Centre for Research on Women’s Health, Aberdeen Maternity Hospital, Aberdeen, AB25 2ZL, UK. Email sohinee.bhattacharya@abdn.ac.uk

Publication History

  1. Issue published online: 16 AUG 2010
  2. Article first published online: 24 JUN 2010
  3. Accepted 15 April 2010. Published Online 24 June 2010.

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Keywords:

  • Intrauterine death;
  • recurrence;
  • stillbirth

Please cite this paper as: Bhattacharya S, Prescott G, Black M, Shetty A. Recurrence risk of stillbirth in a second pregnancy. BJOG 2010;117:1243–1247.

Objective  To examine the risk of recurrence of stillbirth in a second pregnancy.

Design  Retrospective cohort study.

Setting  Scotland, UK.

Population  All women who delivered their first and second pregnancies in Scotland between 1981 and 2005.

Methods  All women delivering for the first time between 1981 and 2000 were linked to records of their second pregnancy using routinely collected data from the Scottish Morbidity Returns. Women who had an intrauterine death in their first pregnancy formed the exposed cohort, whereas those who had a live birth formed the unexposed cohort.

Main outcome measure  Stillbirth in a second pregnancy.

Results  After adjusting for confounding factors, the odds of recurrence of stillbirth in a second pregnancy were found to be 1.94 (99% CI 1.29–2.92) compared with women who had had a live birth in their first pregnancy. Other factors associated with recurrence of stillbirth in a second pregnancy included placental abruption (adjusted OR 1.96; 99% CI 1.60–2.41), preterm delivery (adjusted OR 7.45; 99% CI 5.91–9.39) and low birthweight (adjusted OR 6.69; 99% CI 5.31–8.42). A Bayesian analysis using minimally informative normal priors found the risk of recurrence of stillbirth in a second pregnancy to be 1.59 (99% CI 1.10–2.33).

Conclusions  Women who have stillbirth in their first pregnancy have a higher risk of recurrence in their next pregnancy.

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