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Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia

  1. P Lindgren1,
  2. M Cederholm1,
  3. B Haglund1,2,
  4. O Axelsson1

Article first published online: 17 AUG 2010

DOI: 10.1111/j.1471-0528.2010.02665.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 117, Issue 11, pages 1422–1425, October 2010

Additional Information

How to Cite

Lindgren, P., Cederholm, M., Haglund, B. and Axelsson, O. (2010), Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 1422–1425. doi: 10.1111/j.1471-0528.2010.02665.x

Author Information

  1. 1

    Department of Women’s and Children’s Health/Obstetrics and Gynaecology, Uppsala University, Uppsala, Sweden

  2. 2

    Centre for Epidemiology, The Swedish National Board of Health and Welfare, Stockholm, Sweden

*Dr P Lindgren, Department of Women’s and Children’s Health, Uppsala University, SE 751 85 Uppsala, Sweden. Email peter.lindgren@kbh.uu.se

Publication History

  1. Issue published online: 7 SEP 2010
  2. Article first published online: 17 AUG 2010
  3. Accepted 13 June 2010. Published Online 17 August 2010.

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Keywords:

  • Amniocentesis;
  • chorionic villus sampling;
  • hypertension;
  • pre-eclampsia;
  • pregnancy

Please cite this paper as: Lindgren P, Cederholm M, Haglund B, Axelsson O. Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia. BJOG 2010;117:1422–1425.

The aim was to estimate the risk of maternal hypertensive complications following first- or second-trimester invasive diagnostic procedures, i.e. chorionic villus sampling (CVS) and amniocentesis (AC). Odds ratios (ORs) for gestational hypertension, mild pre-eclampsia or severe pre-eclampsia were calculated for women who underwent CVS (n = 1 984) or AC (n = 21 748) compared with non-exposed women (n = 47 854). No increase in the development of gestational hypertension, mild pre-eclampsia or severe pre-eclampsia was observed. The results do not support an association between invasive procedures for fetal karyotyping and subsequent gestational hypertension or pre-eclampsia.

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