Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth
Article first published online: 13 OCT 2010
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Special Issue: Infections in Pregnancy
Volume 118, Issue 2, pages 136–144, January 2011
How to Cite
Adams Waldorf, K., Rubens, C. and Gravett, M. (2011), Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth. BJOG: An International Journal of Obstetrics & Gynaecology, 118: 136–144. doi: 10.1111/j.1471-0528.2010.02728.x
- Issue published online: 15 DEC 2010
- Article first published online: 13 OCT 2010
- Accepted 12 August 2010. Published Online 13 October 2010.
- nonhuman primate;
- preterm labour
Please cite this paper as: Adams Waldorf K, Rubens C, Gravett M. Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth. BJOG 2011;118:136–144.
Preterm birth is the most important direct cause of neonatal mortality and remains a major challenge for obstetrics and global health. Intrauterine infection causes approximately 50% of early preterm births. Animal models using pregnant mice, rabbits or sheep demonstrate the key link between infection and premature birth, but differ in the mechanisms of parturition and placental structure from humans. The nonhuman primate (NHP) is a powerful model which emulates many features of human placentation and parturition. The contributions of the NHP model to preterm birth research are reviewed, emphasising the role of infections and the potential development of preventative and therapeutic strategies.