Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia
Article first published online: 13 OCT 2010
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 117, Issue 13, pages 1593–1598, December 2010
How to Cite
Shand, A., Nassar, N., Von Dadelszen, P., Innis, S. and Green, T. (2010), Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology, 117: 1593–1598. doi: 10.1111/j.1471-0528.2010.02742.x
- Issue published online: 15 NOV 2010
- Article first published online: 13 OCT 2010
- Accepted 19 August 2010. Published Online 13 October 2010.
- pregnancy outcome;
- vitamin D
Please cite this paper as: Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG 2010;117:1593–1598.
Objective To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes.
Design Prospective cohort study.
Setting Vancouver, British Columbia, Canada (49°N).
Population Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia (n = 221).
Methods Serum 25OHD concentration measured between 10 and 20 weeks of gestation.
Main outcome measures Pre-eclampsia and composite adverse pregnancy outcomes.
Results Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.
Conclusions Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.