• Pre-eclampsia;
  • pregnancy outcome;
  • vitamin D

Please cite this paper as: Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG 2010;117:1593–1598.

Objective  To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes.

Design  Prospective cohort study.

Setting  Vancouver, British Columbia, Canada (49°N).

Population  Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia (n = 221).

Methods  Serum 25OHD concentration measured between 10 and 20 weeks of gestation.

Main outcome measures  Pre-eclampsia and composite adverse pregnancy outcomes.

Results  Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.

Conclusions  Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.