Parvovirus B19 infection in human pregnancy
Article first published online: 13 OCT 2010
© 2010 RCOG No claim to original US government works Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Special Issue: Infections in Pregnancy
Volume 118, Issue 2, pages 175–186, January 2011
How to Cite
Lamont, R., Sobel, J., Vaisbuch, E., Kusanovic, J., Mazaki-Tovi, S., Kim, S., Uldbjerg, N. and Romero, R. (2011), Parvovirus B19 infection in human pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 118: 175–186. doi: 10.1111/j.1471-0528.2010.02749.x
- Issue published online: 15 DEC 2010
- Article first published online: 13 OCT 2010
- Accepted 6 September 2010. Published Online 13 October 2010.
- Fetal anaemia;
- nonimmune hydrops;
Please cite this paper as: Lamont R, Sobel J, Vaisbuch E, Kusanovic J, Mazaki-Tovi S, Kim S, Uldbjerg N, Romero R. Parvovirus B19 infection in human pregnancy. BJOG 2011;118:175–186.
Human parvovirus B19 infection is widespread. Approximately 30–50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy. Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae. B19 infection should be considered in any case of nonimmune hydrops. Diagnosis is mainly through serology and polymerase chain reaction. Surveillance requires sequential ultrasound and Doppler screening for signs of fetal anaemia, heart failure and hydrops. Immunoglobulins, antiviral and vaccination are not yet available, but intrauterine transfusion in selected cases can be life saving.