Parvovirus B19 infection in human pregnancy

Authors

  • RF Lamont,

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Search for more papers by this author
  • JD Sobel,

    1. Department of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Search for more papers by this author
  • E Vaisbuch,

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Search for more papers by this author
  • JP Kusanovic,

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Search for more papers by this author
  • S Mazaki-Tovi,

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Search for more papers by this author
  • SK Kim,

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    Search for more papers by this author
  • N Uldbjerg,

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    Search for more papers by this author
  • R Romero

    1. Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    3. Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA
    Search for more papers by this author

Prof. RF Lamont and Dr R Romero, Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women’s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA. Emails: rlamont@med.wayne.edu and prbchiefstaff@med.wayne.edu

Abstract

Please cite this paper as: Lamont R, Sobel J, Vaisbuch E, Kusanovic J, Mazaki-Tovi S, Kim S, Uldbjerg N, Romero R. Parvovirus B19 infection in human pregnancy. BJOG 2011;118:175–186.

Human parvovirus B19 infection is widespread. Approximately 30–50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy. Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae. B19 infection should be considered in any case of nonimmune hydrops. Diagnosis is mainly through serology and polymerase chain reaction. Surveillance requires sequential ultrasound and Doppler screening for signs of fetal anaemia, heart failure and hydrops. Immunoglobulins, antiviral and vaccination are not yet available, but intrauterine transfusion in selected cases can be life saving.

Ancillary