Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women
Article first published online: 24 DEC 2010
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 118, Issue 4, pages 510–515, March 2011
How to Cite
Cornette, J., Duvekot, J., Roos-Hesselink, J., Hop, W. and Steegers, E. (2011), Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women. BJOG: An International Journal of Obstetrics & Gynaecology, 118: 510–515. doi: 10.1111/j.1471-0528.2010.02794.x
- Issue published online: 10 FEB 2011
- Article first published online: 24 DEC 2010
- Accepted 14 October 2010. Published Online 24 December 2010.
- Cardiac output;
- total vascular resistance
Please cite this paper as: Cornette J, Duvekot J, Roos-Hesselink J, Hop W, Steegers E. Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women. BJOG 2011;118:510–515.
While nifedipine is commonly used for tocolysis, the controversy on its safety remains. So far, the haemodynamic effects on maternal and fetal circulations have not been well documented. Fifteen normotensive women who received 20 mg nifedipine were included in this prospective observational study. The maternal and fetal haemodynamic effects were analysed using maternal echocardiography and fetal Doppler ultrasonography. Nifedipine induced a significant afterload reduction in all women. It triggered a compensatory increase in cardiac output, which maintained blood pressure. These maternal changes had no influence on the uteroplacental and fetal circulations.