The vaginal microbiome: new information about genital tract flora using molecular based techniques
Article first published online: 20 JAN 2011
© 2011 RCOG No claim to original US government works Journal compilation © RCOG 2011 BJOG An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 118, Issue 5, pages 533–549, April 2011
How to Cite
Lamont, R., Sobel, J., Akins, R., Hassan, S., Chaiworapongsa, T., Kusanovic, J. and Romero, R. (2011), The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG: An International Journal of Obstetrics & Gynaecology, 118: 533–549. doi: 10.1111/j.1471-0528.2010.02840.x
- Issue published online: 11 MAR 2011
- Article first published online: 20 JAN 2011
- Accepted 21 November 2010. Published Online 20 January 2011.
- colonisation, culture;
- molecular, vagina
Please cite this paper as: Lamont R, Sobel J, Akins R, Hassan S, Chaiworapongsa T, Kusanovic J, Romero R. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG 2011;118:533–549.
Vaginal microbiome studies provide information that may change the way we define vaginal flora. Normal flora appears dominated by one or two species of Lactobacillus. Significant numbers of healthy women lack appreciable numbers of vaginal lactobacilli. Bacterial vaginosis (BV) is not a single entity, but instead consists of different bacterial communities or profiles of greater microbial diversity than is evident from cultivation-dependent studies. BV should be considered a syndrome of variable composition that results in different symptoms, phenotypical outcomes, and responses to different antibiotic regimens. This information may help to elucidate the link between BV and infection-related adverse outcomes of pregnancy.