Varicella-zoster virus (chickenpox) infection in pregnancy

Authors

  • Ronald F Lamont,

    1.  Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2.  Wayne State University School of Medicine, Department of Obstetrics and Gynaecology, Detroit, MI, USA
    3.  University of Southern Denmark, Department of Obstetrics and Gynaecology, Odense, Denmark
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  • Jack D Sobel,

    1.  Wayne State University School of Medicine, Department of Infectious Diseases, Detroit, MI, USA
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  • D Carrington,

    1.  Health Protection Agency South West, Department of Virology, Myrtle Road, Bristol, UK
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  • Shali Mazaki-Tovi,

    1.  Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2.  Wayne State University School of Medicine, Department of Obstetrics and Gynaecology, Detroit, MI, USA
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  • Juan Pedro Kusanovic,

    1.  Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2.  Wayne State University School of Medicine, Department of Obstetrics and Gynaecology, Detroit, MI, USA
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  • Edi Vaisbuch,

    1.  Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2.  Wayne State University School of Medicine, Department of Obstetrics and Gynaecology, Detroit, MI, USA
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  • Roberto Romero

    1.  Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA
    2.  Wayne State University School of Medicine, Department of Obstetrics and Gynaecology, Detroit, MI, USA
    3.  Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA
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Dr RF Lamont and Dr R Romero, Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women’s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA. Emails rlamont@med.wayne.edu, prbchiefstaff@med.wayne.edu

Abstract

Please cite this paper as: Lamont R, Sobel J, Carrington D, Mazaki-Tovi S, Kusanovic J, Vaisbuch E, Romero R. Varicella-zoster virus (chickenpox) infection in pregnancy. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.02983.x.

Congenital varicella syndrome, maternal varicella-zoster virus pneumonia and neonatal varicella infection are associated with serious fetomaternal morbidity and, not infrequently, mortality. Vaccination against varicella-zoster virus can prevent the disease, and outbreak control limits the exposure of pregnant women to the infectious agent. Maternal varicella-zoster immunoglobulin administration before rash development, with or without antiviral medication, can modify the progression of the disease.

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