Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis
Version of Record online: 20 MAR 2012
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 119, Issue 7, pages 778–787, June 2012
How to Cite
Kleinrouweler, C., Wiegerinck, M., Ris-Stalpers, C., Bossuyt, P., van der Post, J., von Dadelszen, P., Mol, B., Pajkrt, E. and for the EBM CONNECT Collaboration (2012), Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics & Gynaecology, 119: 778–787. doi: 10.1111/j.1471-0528.2012.03311.x
- Issue online: 10 MAY 2012
- Version of Record online: 20 MAR 2012
- Accepted 8 February 2012. Published Online 20 March 2012.
Tables S1–S7. Study characteristics, characteristics of women and test results of all 34 included studies, grouped by biomarker and presentation of results.
Appendix S1. Search strategy for MEDLINE and EMBASE.
Appendix S2. References of studies excluded after screening of full text, as described in Figure 1.
Appendix S3. Forest plots showing standardised mean differences in marker concentration between women who would develop pre-eclampsia and women with uncomplicated pregnancies in all studies reporting data as continuous variables. Negative values indicate lower concentrations; positive values indicate higher concentrations before pre-eclampsia. (A) PlGF; (B) VEGF; (C) sFLT1; and (D) sENG.
Appendix S4. Results of studies on PlGF (A), sFLT1 (B) and sENG (C) reporting sensitivity and specificity of the test, plotted in receiver operating characteristics (ROC) spaces with summary ROC curves. Area of circles is proportional to study sample size.
Appendix S5. Sensitivity analyses that are not reported in the paper.
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