The Lifestyle During Pregnancy Study Group: LS Bakketeig,a CA Boyle,b ME Cogswell,b H-L Falgreen Eriksen,c J Grove,d T Kilburn,c NI Landrø,eÅ Skogerbø,f M Underbjerg,c,g T Wimberleyh aNorwegian Institute of Public Health, Oslo, Norway bCenters for Disease Control and Prevention (CDC), Atlanta, Georgia, USA cDepartment of Public Health, Section of Epidemiology, Aarhus University, Denmark dDepartment of Biomedicine, Faculty of Health Sciences and Bioinformatics Research Centre (BiRC), Aarhus University, Denmark eCenter for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway fInstitute of Public Health, University of Copenhagen, Denmark gChildren’s Neurocenter at Vejlefjord Rehabilitation Center, Vejle, Denmark hDepartment of Public Health, Section of Biostatistics, Aarhus University, Denmark.
The effect of different alcohol drinking patterns in early to mid pregnancy on the child’s intelligence, attention, and executive function
Article first published online: 20 JUN 2012
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 119, Issue 10, pages 1180–1190, September 2012
How to Cite
Kesmodel, U., Bertrand, J., Støvring, H., Skarpness, B., Denny, C., Mortensen, E. and the Lifestyle During Pregnancy Study Group (2012), The effect of different alcohol drinking patterns in early to mid pregnancy on the child’s intelligence, attention, and executive function. BJOG: An International Journal of Obstetrics & Gynaecology, 119: 1180–1190. doi: 10.1111/j.1471-0528.2012.03393.x
The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
- Issue published online: 13 AUG 2012
- Article first published online: 20 JUN 2012
- Accepted 2 April 2012. Published Online 20 June 2012.
- Alcohol consumption;
- binge drinking;
- executive function;
- low to moderate neurodevelopmental effects;
- multiple outcome analyses;
- prenatal exposure;
Please cite this paper as: Kesmodel U, Bertrand J, Støvring H, Skarpness B, Denny C, Mortensen E, the Lifestyle During Pregnancy Study Group. The effect of different alcohol drinking patterns in early to mid pregnancy on the child’s intelligence, attention, and executive function. BJOG 2012;119:1180–1190.
Objective To conduct a combined analysis of the estimated effects of maternal average weekly alcohol consumption, and any binge drinking, in early to mid pregnancy on general intelligence, attention, and executive function in 5-year-old children.
Design Follow-up study.
Setting Neuropsychological testing in four Danish cities 2003–2008.
Population A cohort of 1628 women and their children sampled from the Danish National Birth Cohort.
Methods Participants were sampled based on maternal alcohol consumption during early pregnancy. At age 5 years, the children were tested for general intelligence, attention, and executive function. The three outcomes were analysed together in a multivariate model to obtain joint estimates and P values for the association of alcohol across outcomes. The effects of low to moderate alcohol consumption and binge drinking in early pregnancy were adjusted for a wide range of potential confounding factors.
Main outcome measures Wechsler Preschool and Primary Scale of Intelligence—Revised (WPPSI-R), the Test of Everyday Attention for Children at Five (TEACh-5), and the Behavior Rating Inventory of Executive Functions (BRIEF) scores.
Results Multivariate analyses showed no statistically significant effects arising from average weekly alcohol consumption or any binge drinking, either individually or in combination. These results replicate findings from separate analyses of each outcome variable.
Conclusions The present study contributes comprehensive methodological and statistical approaches that should be incorporated in future studies of low to moderate alcohol consumption and binge drinking during pregnancy. Furthermore, as no safe level of drinking during pregnancy has been established, the most conservative advice for women is not to drink alcohol during pregnancy. However, the present study suggests that small volumes consumed occasionally may not present serious concern.