Perinatal outcomes and gestational weight gain in women with eating disorders: a population-based cohort study

Authors

  • N Micali,

    1.  Behavioural and Brain Sciences Unit, UCL Institute of Child Health, London, UK
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  • B De Stavola,

    1.  Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK
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  • I dos-Santos-Silva,

    1.  Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
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  • J Steenweg-de Graaff,

    1.  The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    2.  Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Centre – Sophia Children’s Hospital, Rotterdam, The Netherlands
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  • PW Jansen,

    1.  Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Centre – Sophia Children’s Hospital, Rotterdam, The Netherlands
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  • VWV Jaddoe,

    1.  The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    2.  Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    3.  Department of Paediatrics, Erasmus Medical Centre – Sophia Children’s Hospital, Rotterdam, The Netherlands
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  • A Hofman,

    1.  Department of Paediatrics, Erasmus Medical Centre – Sophia Children’s Hospital, Rotterdam, The Netherlands
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  • FC Verhulst,

    1.  Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Centre – Sophia Children’s Hospital, Rotterdam, The Netherlands
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  • EAP Steegers,

    1.  Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands
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  • H Tiemeier

    1.  Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Centre – Sophia Children’s Hospital, Rotterdam, The Netherlands
    2.  Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    3.  Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
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N Micali, Behavioural and Brain Sciences Unit, UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK. Email n.micali@ucl.ac.uk

Abstract

Please cite this paper as: Micali N, De Stavola B, dos-Santos-Silva I, Steenweg-de Graaff J, Jansen P, Jaddoe V, Hofman A, Verhulst F, Steegers E, Tiemeier H. Perinatal outcomes and gestational weight gain in women with eating disorders: a population-based cohort study. BJOG 2012;119:1493–1502.

Objective  To investigate adverse perinatal outcomes and gestational weight gain trajectories in women with lifetime (current/past) eating disorders (ED: anorexia nervosa [AN] and bulimia nervosa [BN]).

Design  A longitudinal population-based birth cohort.

Setting  Rotterdam, the Netherlands.

Sample  Women who enrolled prenatally, had complete information on exposure (lifetime ED), and gave birth to a live singleton (n = 5256). Four groups of exposed women: lifetime AN (n = 129), lifetime BN (n = 209), lifetime AN + BN (n = 100), other lifetime psychiatric disorder (n = 1002) were compared with unexposed women (n = 3816).

Methods  Perinatal outcomes and gestational weight gain were obtained from obstetric and midwifery records, self-report and objective measurements. Exposed women were compared with unexposed women within the cohort using linear, logistic regression and mixed models.

Main outcome measures  Any pregnancy, delivery and postnatal complications. Birthweight adjusted for gestational age, prematurity (born <37 weeks), small-for-gestational age; maternal weight gain during pregnancy.

Results  Maternal AN was positively associated with suspected fetal distress. No differences were found in mean birthweight, prevalence of a small-for-gestational-age, or premature birth. Relative to unexposed women, women with AN had, on average, a lower body weight but a higher rate of weight gain subsequently; whereas women with BN had a higher body weight but a lower rate of weight gain.

Conclusions  Maternal lifetime ED is associated with few adverse perinatal outcomes in this sample. Differential gestational weight gain patterns in women with AN and BN are consistent with possible biological compensatory mechanisms aimed at protecting the fetus.

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