Performance of the fullPIERS model in predicting adverse maternal outcomes in pre-eclampsia using patient data from the PIERS (Pre-eclampsia Integrated Estimate of RiSk) cohort, collected on admission

Authors


B Payne, B428A-4500 Oak Street, Vancouver, BC, V6H 3N1, Canada. Email bpayne@cw.bc.ca

Abstract

The fullPIERS (Pre-eclampsia Integrated Estimate of RiSk) model is a promising tool for the prediction of adverse outcomes in pre-eclampsia, developed using the worst values for predictor variables measured within 48 hours of admission. We reassessed the performance of fullPIERS using predictor variables obtained within 6 and 24 hours of admission, and found that the stratification capacity, calibration ability, and classification accuracy of the model remained high. The fullPIERS model is accurate as a rule-in test for adverse maternal outcome, with a likelihood ratio of 14.8 (95% CI 9.1–24.1) or 17.5 (95% CI 11.7–26.3) based on 6- and 24-hour data, respectively, for the women identified to be at highest risk (predicted probability ≥30%).

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